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An integrated proteome database for two-dimensional electrophoresis data analysis and laboratory information management system

Authors
 Sang Yun Cho  ;  Kang-Sik Park  ;  Jung Eun Shim  ;  Min-Seok Kwon  ;  Kil Hong Joo  ;  Won Suk Lee  ;  Joon Chang  ;  Hoguen Kim  ;  Hyun Cheol Chung  ;  Hyun Ok Kim  ;  Young-Ki Paik 
Citation
 PROTEOMICS, Vol.2(9) : 1104-1113, 2002 
Journal Title
PROTEOMICS
ISSN
 1615-9853 
Issue Date
2002
MeSH
Carcinoma, Hepatocellular/metabolism* ; Databasesas Topic* ; Electrophoresis, Gel,Two-Dimensional/methods* ; Humans ; Liver Neoplasms/metabolism* ; Proteome* ; Software
Abstract
We describe an integrated proteome database, termed Yonsei Proteome Research Center Proteome Database (YPRC-PDB) which can store, retrieve and analyze various information including two-dimensional electrophoresis (2-DE) images and associated spot information that were obtained during studies of hepatocellular carcinoma (HCC). YPRC-PDB is also designed to perform as a laboratory information management system that manages sample information, clinical background, conditions of both sample preparation and 2-DE, and entire sets of experimental results. It also features query system and data-mining applications, which are amenable to automatically analyze expression level changes of a specific protein and directly link to clinical information. The user interface is web-based, so that the results from other laboratories can be shared effectively. In particular, the master gel image query is equipped with a graphic tool that can easily identify the relationship between the specific pathological stage of HCC and expression levels of a potential marker protein on the master gel image. Thus, YPRC-PDB is a versatile integrated database suitable for subsequent analyses. The information in YPRC-PDB is updated easily and it is available to authorized users on the World Wide Web (http://yprcpdb.proteomix.org/∼damduck/).
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/1615-9861(200209)2:9%3C1104::AID-PROT1104%3E3.0.CO;2-Q/abstract
DOI
10.1002/1615-9861(200209)2:9<1104::AID-PROT1104>3.0.CO;2-Q
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyun Ok(김현옥) ORCID logo https://orcid.org/0000-0002-4964-1963
Kim, Hogeun(김호근)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/143362
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