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Pemphigus vulgaris 환자의 전신 및 구강증상 발현에 관한 증례보고

Other Titles
 Systemic and Oral Manifestation of Pemphigus vulgaris(Case Report) 
 권병기  ;  안형준  ;  김재홍  ;  최종훈  ;  김종열 
 Journal of Korean Academy of Oral Medicine (대한구강내과학회지), Vol.27(4) : 453-457, 2002 
Journal Title
Journal of Korean Academy of Oral Medicine(대한구강내과학회지)
Issue Date
Pemphigus vulgaris ; Autoimmune disease ; Mucosa and Skin
Pemphigus vulgaris is a serious autoimmune disease that forms blisters on mucosa and skin. It is common in people over 60 years of age, and it has a strong genetic tendency, Autoantibodies can be found in intercelluar spaces between epithelial cells, and because of the autoantibodies for desmosomes, desmosomes that connect the squamous epithelial cells are destroyed. In pemphigus vulgaris, oral lesion is almost always present, and it is often present before skin lesions. Oral lesions can be present anywhere in the oral cavity including the mucosa and gingiva. When it is present in the gingiva, it is in a form of desquamative gingivitis. In severe cases, the entire oral mucosa is involved, and various stages of vesicle formation are manifested. In addition, although the treatment of pemphigus vulgaris is relatively successful, the oral lesion is the last to disappear, and periodic deterioration and alleviation of symptoms is common.
Definite diagnosis for pemphigus vulgaris is based on microscopic examinations including direct immunofluorescence, As in most autoimmune diseases, immunosuppressive drugs are used for treatment. The prognosis should be made carefully considering its chronic progression and side effects of long-term medications. With early diagnosis and appropriate treatment during the initial stage of pemphigus vulgaris, wide skin involvement can be controlled, and need for aggressive treatment with undesirable side effects can be reduced.
In this case report, the continuous treatment of a patient with pemphigus vulgaris was observed in consultation with a dermatologist and a general investigation of pemphigus vulgaris is made.
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Appears in Collections:
2. College of Dentistry (치과대학) > Research Institute (부설연구소) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Orofacial Pain and Oral Medicine (구강내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Hong(김재홍)
Kim, Jong Youl(김종열)
Ahn, Hyoung Joon(안형준)
Choi, Jong Hoon(최종훈) ORCID logo https://orcid.org/0000-0003-3211-3619
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