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외과적 절제로 확진된 폐 대세포암종의 임상 양상

Other Titles
 Clinical features of bronchogenic large cell carcinoma confirmed by surgical resection 
 박무석  ;  신동환  ;  정경영  ;  정재희  ;  정재호  ;  김도훈  ;  김세규  ;  장준  ;  김주항  ;  김성규  ;  김영삼 
 Korean Journal of Medicine (대한내과학회지), Vol.63(5) : 496-506, 2002 
Journal Title
 Korean Journal of Medicine (대한내과학회지) 
Issue Date
Carcinoma ; Large cell ; Diagnosis ; Treatment outcome
Background : To define the final outcome of large cell carcinoma (LCC) after surgical treatment, we reviewed the histopathology, clinical features and follow-up results of 28 cases. Methods : We retrospectively reviewed 28 patients with LCC who underwent surgical resection during the last 15 years from 1986 to 2001 in Severance Hospital. We evaluated clinical data, radiologic findings, pathologic findings, treatment modalities, and survival. Results : The prevalence of LCC was 2.9% (29 cases) among the surgically resected cases in primary lung cancer (1003 cases) during 15 years. The mean age was 59 years old and twenty five cases were male. There were 23 smokers and the average pack year was 33. The cough was the most frequent symptom. Fifteen cases were located in the peripheral part of the lung. Twenty cases consisted of lobulated mass. In chest CT scan, twenty six cases had necrotic portions which appeared to be lower density. Postoperative stage was IA in 1 case (3.6%), IB in 11 cases (39.3%), IIB in 8 cases (28.5%), IIIA in 7 cases (25%), and IV in 1 case (3.6%). Preoperative and postoperative stage concordance rate was 43%. Median survival time was 54.5 months and 5 year-survival rate was 45%. Conclusion : Our results suggest that LCC in the lung is predominant in male and is equally located in the central and peripheral parts of the surgically resected cases. To define the treatment outcome and risk factors of LCC of the lung, further multicenter studies are needed.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Kyu(김세규)
Park, Moo Suk(박무석) ORCID logo https://orcid.org/0000-0003-0820-7615
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