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신경계를 침범하는 혈관염 증후군

Other Titles
 Vasculitic Syndrome with Neurologic Involvement 
 서상원  ;  선우일남  ;  박수철  ;  오원석  ;  김승민 
 Journal of the Korean Neurological Association (대한신경과학회지), Vol.19(4) : 370-375, 2001 
Journal Title
Journal of the Korean Neurological Association(대한신경과학회지)
Issue Date
Vasculitis ; Neurologic manifestations ; Peripheral nerves
Background: The vasculitis are a group of diseases and disorders sharing the central feature of inflammation of the blood vessel wall with attendant tissue ischemia. The purpose of this study was to determine the types and frequency of neurological involvement in patients with vasculitis. Methods: We reviewed the medical records of 131 patients with vasculitis who were examined at Severance Hospital. Results: The nervous system was involved in 47 out of 131 cases. Patients with systemic necrotizing vasculitis showed the highest frequency of neurological involvement (78.3%) of which peripheral involvement was the most common. Patients with Wegener's granulomatosis showed 36.4% of neu-rological involvement of which all cases were cranial nerve palsy. Neurological involvement was found in 18.7% of cases with Takayasu's arteritis and was limited to the central nervous system. Neurological symptoms were initial mani-festations in 56.5% of cases with systemic necrotizing vasculitis, 9% with Wegener's granulomatosis, and 2.7% with Takayasu's arteritis. Among various laboratory values, positive rate of p-ANCA was significantly higher in Wegener's granulomatosis cases with neurological involvement than cases without involvement. Conclusions: We found that the frequency and distribution of neurological involvement vary with the underlying disorder. Neurological manifestations may provide an important clue for the diagnosis of systemic necrotizing vasculitis because neurological involvements frequently occur as an initial manifestation of it.
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1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seung Min(김승민) ORCID logo https://orcid.org/0000-0002-4384-9640
Park, Soo Chul(박수철)
Sunwoo, Il Nam(선우일남)
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