Cited 10 times in
Involvement of phospholipase D in oxidative stress-induced necrosis of vascular smooth muscle cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 신지철 | - |
dc.date.accessioned | 2016-02-19T11:27:19Z | - |
dc.date.available | 2016-02-19T11:27:19Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/143180 | - |
dc.description.abstract | Phospholipase D (PLD) has been associated with necrosis. However, it is not clear whether PLD plays a causative role in this cellular process. We investigated the role of PLD in oxidative stress-induced necrosis of vascular smooth muscle cells (VSMCs). Pervanadate (hydrogen peroxide plus orthovanadate) but not hydrogen peroxide alone activated PLD in a dose- and time-dependent manner. Exposure of VSMCs to pervanadate resulted in necrosis. Pretreatment with butan-1-ol, a PLD inhibitor, attenuated both pervanadate-induced necrosis and increase of intracellular Ca2+. Removal of extracellular Ca2+ inhibited pervanadate-induced necrosis by 50%. These results suggest that PLD activation mediates pervanadate-induced necrosis of VSMCs, which is at least partly due to Ca2+ toxicity. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 277~281 | - |
dc.relation.isPartOf | FEBS LETTERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Aorta/cytology | - |
dc.subject.MESH | Butanols/pharmacology | - |
dc.subject.MESH | Calcium/pharmacology | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Enzyme Activation/drug effects | - |
dc.subject.MESH | Flow Cytometry | - |
dc.subject.MESH | Hydrogen Peroxide/pharmacology | - |
dc.subject.MESH | Muscle, Smooth, Vascular/cytology* | - |
dc.subject.MESH | Muscle, Smooth, Vascular/drug effects | - |
dc.subject.MESH | Muscle, Smooth, Vascular/enzymology* | - |
dc.subject.MESH | Necrosis | - |
dc.subject.MESH | Oxidative Stress*/drug effects | - |
dc.subject.MESH | Phospholipase D/metabolism* | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Vanadates/pharmacology | - |
dc.title | Involvement of phospholipase D in oxidative stress-induced necrosis of vascular smooth muscle cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Rehabilitation Medicine (재활의학) | - |
dc.contributor.googleauthor | Eun-Young Shin | - |
dc.contributor.googleauthor | Do Sik Min | - |
dc.contributor.googleauthor | Ji-Cheol Shin | - |
dc.contributor.googleauthor | Kyung-Sun Shin | - |
dc.contributor.googleauthor | Min-Soo Hyun | - |
dc.contributor.googleauthor | Kwon-Soo Ha | - |
dc.contributor.googleauthor | Hun-Sik Kim | - |
dc.contributor.googleauthor | Hee-Yul Ahn | - |
dc.contributor.googleauthor | Eung-Gook Kim | - |
dc.identifier.doi | 10.1016/S0014-5793(01)03059-9 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02162 | - |
dc.relation.journalcode | J00890 | - |
dc.identifier.eissn | 1873-3468 | - |
dc.identifier.pmid | 11718730 | - |
dc.subject.keyword | Phospholipase D | - |
dc.subject.keyword | Pervanadate | - |
dc.subject.keyword | Necrosis | - |
dc.subject.keyword | Vascular smooth muscle cell | - |
dc.contributor.alternativeName | Shin, Ji Cheol | - |
dc.contributor.affiliatedAuthor | Shin, Ji Cheol | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 508 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 277 | - |
dc.citation.endPage | 281 | - |
dc.identifier.bibliographicCitation | FEBS LETTERS, Vol.508(2) : 277-281, 2001 | - |
dc.identifier.rimsid | 39116 | - |
dc.type.rims | ART | - |
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