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Serum Leptin, IGF-I and Insulin Levels in Preterm Infants Receiving Parenteral Nutrition During the First Week of Life

Authors
 M.J. Park  ;  R. Namgung  ;  J.N. Kim  ;  D.H. Kim 
Citation
 JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, Vol.14(4) : 429-433, 2001 
Journal Title
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
ISSN
 0334-018X 
Issue Date
2001
MeSH
Aging ; Body Mass Index ; Female ; Gestational Age ; Humans ; Infant, Newborn ; Infant, Premature/blood* ; Insulin/blood* ; Insulin-Like Growth Factor I/analysis* ; Leptin/analysis* ; Male ; Parenteral Nutrition* ; Weight Loss/physiology
Keywords
leptin ; IGF-I ; insulin ; preterm infants
Abstract
Leptin is involved in the regulation of body weight through a feedback signal between adipose tissue and the satiety center, to decrease food intake and increase energy expenditure. Newborn infants experience physiological weight loss during the first week of life. The leptin level may be decreased to enhance food intake and to decrease energy expenditure for physiological adaptation during early postnatal days. Insulin-like growth factor-I (IGF-I) and insulin are involved in the regulation of perinatal growth. Leptin might be interrelated with IGF-I or insulin, since both of these have adipogenic and somatotropic effects. We therefore hypothesized that leptin, IGF-I and insulin would be decreased during the first week of life, concurrently with physiological weight loss. Thirty preterm AGA infants (birth weight 1.574+/-313 g; GA 31.9+/-2.2 wk) were studied. All infants received parenteral nutrition from the third day after birth. Leptin was significantly decreased during the first week of life, and insulin was significantly increased at day 7 vs. day 1 and day 3. IGF-I did not change during the first week of life. Leptin was positively correlated with body weight (r = 0.368, p<0.01), body mass index (r = 0.267, p<0.05), and serum IGF-I (r = 0.330, p <0.01), but not with serum insulin. The percent of weight reduction during the first week of life was not correlated with the percent of leptin reduction during the first week of life. In conclusion, leptin was significantly decreased and positively correlated with body weight and IGF-I during the first week of life. Changes of leptin and insulin might be related to postnatal adaptation in metabolism, but the exact role of leptin, IGF-I and insulin in postnatal physiological weight loss is not clear.
Full Text
http://www.degruyter.com/view/j/jpem.2001.14.4/jpem.2001.14.4.429/jpem.2001.14.4.429.xml
DOI
10.1515/JPEM.2001.14.4.429
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Duk Hee(김덕희)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/143059
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