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Plasma fibronectin levels in ischemic heart disease

Authors
 Kyung Soon Song  ;  Hyun Kyung Kim  ;  Wonhm Shim  ;  Sun Ha Jee 
Citation
 ATHEROSCLEROSIS, Vol.154(2) : 449-453, 2001 
Journal Title
 ATHEROSCLEROSIS 
ISSN
 0021-9150 
Issue Date
2001
MeSH
Adult ; Aged ; Aged, 80 and over ; Biomarkers/blood ; Blood Pressure ; Cholesterol/blood ; Coronary Angiography ; Disease Progression ; Female ; Fibronectins/blood* ; Humans ; Hypertension/blood ; Hypertension/complications ; Hypertension/physiopathology ; Male ; Middle Aged ; Myocardial Ischemia/blood* ; Myocardial Ischemia/complications ; Myocardial Ischemia/diagnostic imaging ; Myocardial Ischemia/physiopathology ; Odds Ratio ; Risk Factors ; Triglycerides/blood
Keywords
Fibronectin ; Ischemic heart disease ; Atherosclerosis ; Hypertension
Abstract
Fibronectin is a paradigm adhesive protein which has been implicated in the regulation of several cellular processes and cell-cell interactions. Large amounts of fibronectin have been detected in atherosclerotic plaques, while hypertension in animal models has been shown to rapidly increase fibronectin expression in arterial walls. The aim of the present study was to determine the levels of plasma fibronectin (FN) in 133 patients with ischemic heart disease and in 36 normal controls, and to investigate the possible association with blood pressure. Plasma FN levels in patients with ischemic heart disease were found to be significantly elevated (mean±S.D.; 46.5±14.2 mg/dl) compared with the control group (38.0±14.2 mg/dl) (P=0.002). Plasma FN concentrations were significantly different between the hypertensive group (52.9±14.5 mg/dl) and the normal blood pressure group (41.4±11.8 mg/dl) among the patients with ischemic heart disease (P<0.001). Plasma FN concentration was positively correlated with total cholesterol, triglyceride, systolic blood pressure and body mass index. In conclusion, the plasma fibronectin level may have pathogenetic implications in association with lipid components and blood pressure in patients with ischemic heart disease.
Full Text
http://www.sciencedirect.com/science/article/pii/S0021915000004901
DOI
10.1016/S0021-9150(00)00490-1
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/143049
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