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부적절하게 조절되는 소아 간질 환자에서 Topiramate의 병용투여 효과

Other Titles
 Topiramate in Pediatric Subjects with Inadequately Controlled Epilepsy : Open-Label Phase IV Multicenter Trial 
 이문향  ;  조강호  ;  황경태  ;  이인구  ;  은백린  ;  김준식  ;  권순학  ;  정사준  ;  황규근  ;  남상욱  ;  김영창  ;  서은숙  ;  황용승  ;  김기중  ;  문한구  ;  고태성  ;  황태규  ;  김홍동  ;  이건수  ;  김원섭  ;  정희정  ;  김선우 
 Journal of the Korean Child Neurology Society, Vol.9(1) : 69-79, 2001 
Journal Title
Journal of the Korean Child Neurology Society(대한소아신경학회지)
Issue Date
Topiramate ; Pediatric epilepsy ; Partial seizures ; Lennox-Gastaut syndrome
Purpose: To evaluate the efficacy and safety of topiramate up to 9㎎, ㎏, day in children as adjunctive therapy for inadequately controlled partial seizures with or without secondary generalization and Lennox-Gastaut syndrome.
Methods: This study was a prospective, multicenter, add-on, and open-label study. Patients between age 2 to 16 years with previous 4 weeks seizure record were treated with topiramate for 24 weeks. Study design consisted of a 4 weeks baseline phase, a 12 weeks of titration phase, and a 12 weeks stabilization period. Efficacy was primarily assessed by measuring median seizure frequency reduction rate and other efficacy variables included responder rate, seizure free rate, and global evaluation by investigators and parents. Treatment emergent adverse events were also investigated.
Results: Among 192 patients screened, 184 patients were included for efficacy measurement by intention-to-treat analysis. Median seizure frequency reduction rate were 62.2% during the entire period and 67.1% during the stabilization period. Responder rate were 59.2% during the entire period and 60.9% during the stabilization period. Seizure free rate were 6.5% during the entire period and 16.3% during the stabilization period. The incidence of treatment emergent adverse events was 44% with anorexia and somnolence being the most frequent. 64.3% of patients with adverse events reported resolution of adverse effects during the trial.
Conclusion: Results in this cohort of 184 patients with refractory seizures show topiramate to be highly effective and sage and add-on therapy in medically refractory partial seizures and Lennox-Gastaut syndrome in pediatric population.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Heung Dong(김흥동) ORCID logo https://orcid.org/0000-0002-8031-7336
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