뇌혈관장애에서 인지유발전위검사의 유용성

Abstract

Objectives：The purpose of this study is to evaluate the clinical applicability of cognitive evoked potentials (CEPs) to identify the cognitive disorder in cerebrovascular diseases (CVD). Methods：The P3 latencies, amplitudes and latency to amplitude ratios (LARs) of CEPs were measured in 25 healthy controls and 35 patients with CVD. The association of CEPs with variables including age, sex, Mini-Mental State Examination (MMSE), CVD types, loci of hemiplegic limbs, duration, education, Brief Psychiatric Rating Scale (BPRS), and Instrumental Activities of Daily Living (IADL) were also analyzed. Results：1) The P3 latencies (447.87±113.06 msec) and LARs (65.83±43.25) were prolonged in CVD (p<0.01), while the amplitudes (8.18±2.51 μV) were not changed. 2) The P3 latencies (537.31±101.14 msec) and LARs (94.89±46.44) in CVD with MMSE <24 were prolonged, and the amplitudes (6.45±1.98 μV) were reduced significantly (p<0.01, respectively), as compared with those in CVD with MMSE≥24 (363.39±19.67 msec, 38.40± 8.37 and 9.81±1.76 μV, respectively). 3) The BPRS and IADL in CVD with MMSE<24 were significantly (p<0.01) different from those in CVD with MMSE≥24. 4) On analyzing the association of CEPs with variables in CVD, the P3 latencies were correlated positively with age, BPRS and IADL, while negatively with MMSE and DLFA. The amplitudes were correlated positively with MMSE, while negatively with age, BPRS and IADL. The LARs were correlated positively with age, BPRS and IADL, while negatively with MMSE. 5) On analyzing the association of CEPs with variables in CVD with MMSE≥24, the P3 latencies were correlated positively with age, while negatively with MMSE. The amplitudes and LARs were not correlated with variables. 6) On analyzing the association of CEPs with variables in CVD with MMSE<24, the P3 latencies were correlated positively with BPRS, while negatively with MMSE. The amplitudes were positively correlated with age. The LARs were positively correlated with IADL. Conclusions：The P3 latencies and LARs of cognitive evoked potentials seemed to a useful clinical measures to assess cognitive disorders in CVD.