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Hemodynamic Effects on Atherosclerosis-Prone Coronary Artery: Wall Shear Stress / Rate Distribution and Impedance Phase Angle in Coronary and Aortic Circulation

Authors
 Byoung Kwon Lee  ;  Hyuck Moon Kwon  ;  Bum Kee Hong  ;  Byung Eun Park  ;  Sang Ho Suh  ;  Min Tae Cho  ;  Chong Sun Lee  ;  Min Cheul Kim  ;  Charn Jung Kim  ;  Sang Sin Yoo  ;  Hyun Seung Kim 
Citation
 YONSEI MEDICAL JOURNAL, Vol.42(4) : 375-383, 2001 
Journal Title
YONSEI MEDICAL JOURNAL
ISSN
 0513-5796 
Issue Date
2001
MeSH
Adult ; Aged ; Aorta, Abdominal/physiology* ; Arteriosclerosis/etiology ; Arteriosclerosis/physiopathology* ; Coronary Circulation ; Coronary Vessels/physiology* ; Electric Impedance ; Female ; Hemodynamics* ; Humans ; Male ; Middle Aged ; Stress, Mechanical
Keywords
Coronary artery ; shear stress/rate ; and phase angle
Abstract
The objective of the present study was to evaluate the hemodynamic characteristics of an atherosclerosis-prone coronary artery compared to the aorta. We describe three-dimensional spatial patterns of wall shear stress (WSS) according to the impedance phase angle in pulsatile coronary and aorta models using in vivo hemodynamic parameters and computed numerical simulations both qualitatively and quantitatively. Angiography of coronary arteries and aortas were done to obtain a standard model of vascular geometry. Simultaneously to the physiologic studies, flow-velocity and pressure profiles from in vivo data of the intravascular Doppler and pressure wire studies allowed us to include in vitro numerical simulations. Hemodynamic variables, such as flow-velocity, pressure and WSS in the coronary and aorta models were calculated taking into account the effects of vessel compliance and phase angle between pressure and flow waveforms. We found that there were spatial fluctuations of WSS and in the recirculation areas at the curved outer wall surface of the coronary artery. The mean WSS of the calculated negative phase angle increased in the coronary artery model over that in the aorta model and the phase angle effect was most prominent on the calculated amplitude of WSS of the coronary artery. This study suggests that the rheologic property of coronary circulation, such as the fluctuation of WSS/WSR induces several hemodynamic characteristics. A separation of flow-velocity, a difference in phase between pressure conductance and blood flow and prominent temporal and/or spatial oscillatory fluctuations of the shear forces as a function of pulsatile flow might be important factors in atherogenesis and progression of atherosclerosis.
Files in This Item:
T200103389.pdf Download
DOI
10.3349/ymj.2001.42.4.375
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Hyuck Moon(권혁문) ORCID logo https://orcid.org/0000-0001-9901-5015
Hong, Bum Kee(홍범기) ORCID logo https://orcid.org/0000-0002-6456-0184
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/142943
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