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Segregation of Human Neural Stem Cells in the Developing Primate Forebrain

Authors
 Václav Ourednik  ;  Jitka Ourednik  ;  Jonathan D. Flax  ;  W. Michael Zawada  ;  Cynthia Hutt  ;  Chunhua Yang  ;  Kook I. Park  ;  Seung U. Kim  ;  Richard L. Sidman  ;  Curt R. Freed  ;  Evan Y. Snyder 
Citation
 SCIENCE, Vol.293(5536) : 1820-1824, 2001 
Journal Title
 SCIENCE 
ISSN
 0036-8075 
Issue Date
2001
MeSH
Animals ; Brain Tissue Transplantation ; Cell Differentiation ; Cell Lineage ; Cell Movement* ; Cell Transplantation ; Clone Cells/cytology ; Clone Cells/transplantation ; Humans ; Macaca radiata/embryology ; Neocortex/cytology* ; Neocortex/embryology* ; Neurons/cytology* ; Neurons/transplantation ; Prosencephalon/cytology* ; Prosencephalon/embryology* ; Stem Cell Transplantation ; Stem Cells/cytology* ; Transplantation, Heterologous
Abstract
Many central nervous system regions at all stages of life contain neural stem cells (NSCs). We explored how these disparate NSC pools might emerge. A traceable clone of human NSCs was implanted intraventricularly to allow its integration into cerebral germinal zones of Old World monkey fetuses. The NSCs distributed into two subpopulations: One contributed to corticogenesis by migrating along radial glia to temporally appropriate layers of the cortical plate and differentiating into lamina-appropriate neurons or glia; the other remained undifferentiated and contributed to a secondary germinal zone (the subventricular zone) with occasional members interspersed throughout brain parenchyma. An early neurogenetic program allocates the progeny of NSCs either immediately for organogenesis or to undifferentiated pools for later use in the “postdevelopmental” brain.
Files in This Item:
T200103382.pdf Download
DOI
10.1126/science.1060580
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Park, Kook In(박국인) ORCID logo https://orcid.org/0000-0001-8499-9293
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/142940
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