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Mechanism of Carbon Monoxide-Induced Relaxation in the Guinea Pig Ileal Smooth Muscle

 Seongchun KWON  ;  Seungsoo CHUNG  ;  Ducksun AHN  ;  Dongsoo YEON  ;  Taicksang NAM 
 Journal of Veterinary Medical Science, Vol.63(4) : 389-393, 2001 
Journal Title
 Journal of Veterinary Medical Science 
Issue Date
The mechanism of carbon monoxide (CO)-induced relaxation were investigated in the guinea-pig ileum. CO (10%) inhibited the 40 mM KCl-induced contraction. This effect was antagonized by ODQ (1 μM), a soluble guanylate cyclase inhibitor. In contrast, CO did not inhibit the 40 mM KCl-induced increase in cytosolic Ca2+ level ([Ca2+]i). Cumulative addition of KCl induced a graded increase in both [Ca 2+]i and muscle tension. In the presence of CO, the increase in muscle tension was attenuated whereas the increase in [Ca2+]i was only slightly decreased. Thus, the [Ca2+]i-tension relationship constructed by cumulative addition of KCl shifted downwards in the presence of CO. Using the patch clamp, CO was found to have little effect on the peak Ba currents (IBa) when voltage was stepped from -60 mV to 0 mV. From these results, we conclude that CO inhibits contraction of guinea-pig ileum mainly by the decrease in the sensitivity of contractile elements to Ca2+ via a cyclic GMP-dependent pathway but not by the inhibition of L-type Ca2+ channel.
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1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
남택상(Nam, Taick Sang)
안덕선(Ahn, Duk Sun) ORCID logo https://orcid.org/0000-0001-9351-6951
연동수(Yeon, Dong Soo)
정승수(Chung, Seung Soo) ORCID logo https://orcid.org/0000-0002-3119-9628
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