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반복적인 이온영동에 의한 표피 calcium gradient의 변화가 피부장벽상태에 미치는 영향

Other Titles
 The Effect of Repeated Changes in the Epidermal Calcium Gradient by Repeated Iontophoresis on the Skin Barrier 
Authors
 최응호  ;  안성구  ;  이승헌 
Citation
 Journal of Skin Barrier Research (한국피부장벽학회지), Vol.3(1) : 62-67, 2001 
Journal Title
Journal of Skin Barrier Research(한국피부장벽학회지)
ISSN
 1229-4934 
Issue Date
2001
Keywords
skin barrier ; iontophoresis ; epidermal calcium gradient
Abstract
Background: The calcium ion is important in skin barrier homeostasis. Disruption of the skin barrier increases transepidermal water loss(TEWL), and induces the loss of the epidernal calcium gradient, lamellar body(LB) secretion, epidermal
lipid
synthesis and epidermal DNA synthesis. Our previous research showed that iontophoresis induced the disappearance of the epidermal calcium gradient and increase in LB secretion without an increase of TEWL.

Purpose: To elucidate whether repeated changes in the epidermal calcum gradient induced by repeated iontophoresis can induce skin barrier damage, epidermal proliferation or enhance the skin barrier to irritants.

Methods: 8 to 12 week old hairless mice were used. For the group defining skin barrier damage and epidermal proliferation, iontophoresis was currented for 1h and 2h a day and repeated for 7 days. TEWL was measured at 24h after iontophoresis
each
day. Skin specimens were taken for measuring the epidermal thichness under light microsocope and observing the stratum corneum(SC) intercellular spaces under electron microscope. For the other group defining skin barrier enhancement to irritants,
iontophoresis was currlented for 3/4h twice a day and repeated for 3 days and then 1% SLS was applied for 1h. TEWL was checked for barrier recovery rate at 15 min, 6h, 12h, 24h, 48h after the 1% SLS application.

Results: We could not find any skin barrier damage represented by TEWL, eidermal proliferation or any remarkable changes of SC intercellular spaces over the control. The barrier recovery in iontophoresis skin was accelerated at 6h, but not
different after 12h compared to control skin.

Conclusion: Repeated changes of the epidermal calcium gradient without barrier damage can not induce epidermal proliferation, and repeated iontophoresis can enhance the skin barrier.
Full Text
http://kiss.kstudy.com/journal/thesis_name.asp?tname=kiss2002&key=2593654
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Seung Hun(이승헌)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/142905
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