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위암 발생과정에서 β-Catenin의 역할

Other Titles
 β-Catenin Expression in Gastric Carcinogenesis 
Authors
 강혜윤  ;  최연락  ;  김호근 
Citation
 KOREAN JOURNAL OF PATHOLOGY , Vol.35(5) : 376-382, 2001 
Journal Title
 KOREAN JOURNAL OF PATHOLOGY 
ISSN
 0379-1149 
Issue Date
2001
Keywords
Stomach neoplasms ; Beta catenin ; Cadherins ; Microsatellite repeats
Abstract
Background: The molecular pathogenesis of gastric carcinoma is not yet well characterized. The purpose of this study is to assess the role of β-catenin in gastric carcinogenesis. Methods: We analyzed β-catenin expression using immunohistochemistry on 68 gastric adenomas and 34 gastric adenocarcinomas, and compared the result with pathological and molecular types of tumors and E-cadherin expression. Results: Nuclear expression of β-catenin was noted more frequently in gastric adenomas than in carcinomas (40% vs. 21%, 0.05≤p<1). There was no significant relationship between nuclear β-catenin expression and histologic degree of adenoma, histologic type of carcinoma or microsatellite instability. E-cadherin expression showed significantly more frequent decrease in the membrane stainability of carcinomas compared to adenomas (p<0.01). Conclusions: The frequent nuclear β-catenin expression in gastric adenomas suggests that the β-catenin alteration might play an early role in gastric carcinogenesis.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hogeun(김호근)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/142894
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