Cited 4 times in

Clinicopathologic study of Wegener's granulomatosis with special emphasis on early lesions in 10 Korean patients

DC Field Value Language
dc.contributor.author김종윤-
dc.contributor.author박용범-
dc.contributor.author신동환-
dc.contributor.author이수곤-
dc.contributor.author인요한-
dc.contributor.author정현주-
dc.date.accessioned2016-02-19T11:19:11Z-
dc.date.available2016-02-19T11:19:11Z-
dc.date.issued2001-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/142882-
dc.description.abstractWe reviewed ten cases of Wegener's granulomatosis with special emphasis on the characteristics of the early stage of Wegener's granulomatosis. All patients presented with nonspecific symptoms and signs, so that Wegener's granulomatosis was not initially considered. However, half of the patients had clinical or radiologic disease in the nose/or paranasal sinuses as the primary presenting problems and showed neutrophil microabscess surrounded by palisading epithelioid cells and irregularly arranged giant cells in the nasal biopsy as the most characteristic feature. Five of ten patients were believed to have a protracted superficial phenomenon before involvement of other organs, specifically the lung or kidney. Four of ten patients showed nonreactivity to ANCA test at the time of presentation. Although the number of cases reviewed in this study was small, the rate of nonreactivity to ANCA was higher than those of the larger series. The importance of early diagnosis of Wegener's granulomatosis can not be overemphasized in view of the fact that cases unrecognized clinicopathologically finally progress to full-blown systemic form of Wegener's granulomatosis with poor prognosis. The diagnosis of Wegener's granulomatosis should be based on a thorough and meticulous examination of its characteristic histologic changes in biopsied tissue particularly extravascular foci.-
dc.description.statementOfResponsibilityopen-
dc.format.extent46~54-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAntibodies, Antineutrophil Cytoplasmic/blood-
dc.subject.MESHFemale-
dc.subject.MESHGranulomatosis with Polyangiitis/diagnosis-
dc.subject.MESHGranulomatosis with Polyangiitis/drug therapy-
dc.subject.MESHGranulomatosis with Polyangiitis/pathology*-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRetrospective Studies-
dc.titleClinicopathologic study of Wegener's granulomatosis with special emphasis on early lesions in 10 Korean patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorYong Beom Park-
dc.contributor.googleauthorJong Yoon Kim-
dc.contributor.googleauthorJohn A Linton-
dc.contributor.googleauthorHyeon Joo Jung-
dc.contributor.googleauthorSoo Kon Lee-
dc.contributor.googleauthorDong Hwan Shin-
dc.identifier.doi10.3349/ymj.2001.42.1.46-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00926-
dc.contributor.localIdA01579-
dc.contributor.localIdA02098-
dc.contributor.localIdA02889-
dc.contributor.localIdA03352-
dc.contributor.localIdA03771-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid11293501-
dc.subject.keywordWegener's granulomatosis-
dc.subject.keywordantineutrophil cytoplasmic antibody-
dc.subject.keywordnasal biopsy-
dc.subject.keywordearly diagnosis-
dc.subject.keywordprotracted superficial phenomenon-
dc.contributor.alternativeNameKim, Jong Youn-
dc.contributor.alternativeNamePark, Yong Beom-
dc.contributor.alternativeNameShin, Dong Hwan-
dc.contributor.alternativeNameLee, Soo Kon-
dc.contributor.alternativeNameLinton, John A.-
dc.contributor.alternativeNameJeong, Hyeon Joo-
dc.contributor.affiliatedAuthorKim, Jong Youn-
dc.contributor.affiliatedAuthorPark, Yong Beom-
dc.contributor.affiliatedAuthorShin, Dong Hwan-
dc.contributor.affiliatedAuthorLee, Soo Kon-
dc.contributor.affiliatedAuthorLinton, John A.-
dc.contributor.affiliatedAuthorJeong, Hyeon Joo-
dc.rights.accessRightsfree-
dc.citation.volume42-
dc.citation.number1-
dc.citation.startPage46-
dc.citation.endPage54-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.42(1) : 46-54, 2001-
dc.identifier.rimsid39548-
dc.type.rimsART-
Appears in Collections:
6. Others (기타) > International Health Care Center (국제진료소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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