Cited 63 times in
Detection of Phenolic Glycolipid I of Mycobacterium leprae in Sera from Leprosy Patients before and after Start of Multidrug Therapy
DC Field | Value | Language |
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dc.contributor.author | 조상래 | - |
dc.date.accessioned | 2016-02-19T11:18:09Z | - |
dc.date.available | 2016-02-19T11:18:09Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 1071-412X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/142844 | - |
dc.description.abstract | A total of 100 untreated new leprosy patients were recruited prospectively and examined for the presence of phenolic glycolipid I (PGL-I) antigen in their serum specimens by dot enzyme-linked immunosorbent assay (ELISA) using rabbit anti-PGL-I antiserum. The presence of circulating PGL-I antigen was closely related to the bacterial indices (BI) of the patients. The PGL-I antigen was detectable in 27 (93.1%) of 29 patients with a BI of 4.0 or above and in 15 (68.2%) of 22 patients with a BI of 3.0 to 3.9. However, none of the 37 patients with a BI of less than 1.9 had detectable PGL-I antigen by the methods used in this study. The level of PGL-I in serum declined rapidly by about 90% 1 month after the start of multidrug therapy. This study showed clearly that anti-PGL-I IgM antibodies and circulating PGL-I antigen levels reflect the bacterial loads in untreated leprosy patients. The serological parameters based on the PGL-I antigen may therefore be useful in the assessment of leprosy patients at the time of diagnosis and possibly in monitoring patients following chemotherapy. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 138~142 | - |
dc.relation.isPartOf | CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Antigens, Bacterial/blood* | - |
dc.subject.MESH | Enzyme-Linked Immunosorbent Assay/methods | - |
dc.subject.MESH | Glycolipids/blood* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Leprostatic Agents/therapeutic use | - |
dc.subject.MESH | Leprosy/blood | - |
dc.subject.MESH | Leprosy/drug therapy | - |
dc.subject.MESH | Leprosy/immunology | - |
dc.subject.MESH | Leprosy/microbiology* | - |
dc.subject.MESH | Mycobacterium leprae/immunology* | - |
dc.subject.MESH | Prospective Studies | - |
dc.title | Detection of Phenolic Glycolipid I of Mycobacterium leprae in Sera from Leprosy Patients before and after Start of Multidrug Therapy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학) | - |
dc.contributor.googleauthor | Sang-Nae Cho | - |
dc.contributor.googleauthor | Roland V. Cellona | - |
dc.contributor.googleauthor | Laarni G. Villahermosa | - |
dc.contributor.googleauthor | Tranquilino T. Fajardo, Jr. | - |
dc.contributor.googleauthor | M. Victoria F. Balagon | - |
dc.contributor.googleauthor | Rodolfo M. Abalos | - |
dc.contributor.googleauthor | Esterlina V. Tan | - |
dc.contributor.googleauthor | Gerald P. Walsh | - |
dc.contributor.googleauthor | Joo-Deuk Kim | - |
dc.contributor.googleauthor | Patrick J. Brennan | - |
dc.identifier.doi | 10.1128/CDLI.8.1.138-142.2001 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03824 | - |
dc.relation.journalcode | J00547 | - |
dc.identifier.eissn | 1098-6588 | - |
dc.identifier.pmid | 11139208 | - |
dc.contributor.alternativeName | Cho, Sang Nae | - |
dc.contributor.affiliatedAuthor | Cho, Sang Nae | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 8 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 138 | - |
dc.citation.endPage | 142 | - |
dc.identifier.bibliographicCitation | CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY , Vol.8(1) : 138-142, 2001 | - |
dc.identifier.rimsid | 29894 | - |
dc.type.rims | ART | - |
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