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Experimental studies on the antiviral agent famciclovir in Behçet's disease symptoms in ICR mice.

Authors
 S. Sohn  ;  D. Bang  ;  E-S. Lee  ;  H.J. Kwon  ;  S.I. Lee  ;  S. Lee 
Citation
 BRITISH JOURNAL OF DERMATOLOGY, Vol.145(5) : 799-804, 2001 
Journal Title
 BRITISH JOURNAL OF DERMATOLOGY 
ISSN
 0007-0963 
Issue Date
2001
MeSH
2-Aminopurine/analogs & derivatives* ; 2-Aminopurine/therapeutic use* ; Animals ; Antiviral Agents/therapeutic use* ; Behcet Syndrome/drug therapy* ; Behcet Syndrome/immunology ; Behcet Syndrome/virology ; Disease Models, Animal ; Famciclovir ; Herpes Simplex/complications ; Herpes Simplex/drug therapy ; Interleukin-2/metabolism ; Mice ; Mice, Inbred ICR ; Prodrugs/therapeutic use* ; Recurrence ; Reverse Transcriptase Polymerase Chain Reaction
Keywords
behçet's disease ; cytokine ; famciclovir ; herpes simplex virus
Abstract
BACKGROUND: Chronic oral aphthae, recurrent genital ulcers and uveitis are the three main manifestations of Behçet's disease (BD). The aetiopathogenesis of BD is still obscure, but herpes simplex virus (HSV) is one of the possible causal factors. Various kinds of drugs, including immunosuppressants and aciclovir have been used in treatment, but effectiveness is variable. OBJECTIVES: To demonstrate the efficacy of famciclovir, an antiviral compound that acts against HSV, varicella-zoster virus and hepatitis B virus, in a murine model of BD. METHODS: Using the HSV-induced BD mouse model, famciclovir was administered variously before and after inoculation or from the day of lesion occurrence, with appropriate controls. Ulceration of the mouth and genital skin and eye involvement were monitored. In addition, spleen cytokine expression was measured by polymerase chain reaction. RESULTS: Pretreatment and concurrent treatment did not affect the occurrence of BD, but treatment from the appearance of lesions was effective in improving BD and preventing recurrence. After famciclovir, interleukin 2 expression correlated with the recurrence of BD symptoms. CONCLUSIONS: This model suggests the possible role of immune response to viral infection in the development and activation of BD. The study provides a rationale for clinical trials of famciclovir in the human form of BD.
Full Text
http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2133.2001.04498.x/abstract
DOI
10.1046/j.1365-2133.2001.04498.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Bang, Dong Sik(방동식)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/142831
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