161 186

Cited 0 times in

Ketamine이 청각 기억에 미치는 영향 : Mismatch Negativity와 정신분열병의 Glutamate 가설

Other Titles
 Effect of Ketamine on the Echoic Memory Process : The Mismatch Negativity and Glutamate Receptor System in Schizophrenia 
 윤탁  ;  안경흡  ;  배지수  ;  김명선  ;  김재진  ;  권준수 
 Korean Journal of Psychopharmacology (대한정신약물학회지), Vol.12(4) : 322-327, 2001 
Journal Title
 Korean Journal of Psychopharmacology (대한정신약물학회지) 
Issue Date
Schizophrenia ; Information process ; NMDA receptor ; Mismatch negativity ; Echoic memory
Objective: The abnormality of mismatch negative (MMN) in schizophrenia is thought to be associated with perceptional disturbance and cognitive dysfunction. And the antagonists of the N-methyl-D-aspartate (NMDA) receptors, ketamine, can induce anomalies of psychophysiology and cognitive function as those of schizophrenia. In order to explore the role of NMDA receptors on echoic memory system, MMN under ketamine administration was analyzed. Methods: MMNs of Healthy 12 subjects under subanesthetic dose (0.65 ㎎/㎏/hr) of ketamine administration in placebo-controlled design were recorded by 128 channel EEG. Brief Psychiatric Rating Scale (BPRS) change was also evaluated. Results: BPRS score was significantly increased by ketamine administration (t=-6.655, p<0.005). Ketamine induced significant decrease in MMN amplitudes (Fz, t=-2.572, p=0.026). Neither MMN amplitude under placebo administration nor MMN latencies under ketamine administration and placebo was changed significantly. Conclusion: Ketamine induced echoic memory dysfunction in healthy subjects, which is usually found in schizophrenic patients. Consequently, reduced glutamatergic activity in brain could be involved some early processes of the memory dysfunction in schizophrenia.
Files in This Item:
T200103109.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.