0 75

Cited 0 times in

Prognostic role of cyclin D1 in retroperitoneal sarcomas

Authors
 S. H. Kim  ;  N. H. Cho  ;  G. Tallini  ;  M. Dudas  ;  J. J. Lewis  ;  C. Cordon-Cardo 
Citation
 Cancer, Vol.91(2) : 428-434, 2001 
Journal Title
 Cancer 
ISSN
 0008-543X 
Issue Date
2001
Abstract
PURPOSE: Cyclin D1 regulates the G1 checkpoint of the cell cycle and is overexpressed in a number of cancers. This study was designed to determine if cyclin D1 overexpression had prognostic value in patients undergoing surgery with curative intent for primary retroperitoneal soft-tissue sarcoma. METHODS: Tissue was available for analysis on 79 patients who underwent resection between September 1983 and May 1997. Clinicopathologic data and follow-up was obtained from a prospective sarcoma database and a patient and family interview. Immunohistochemical analysis was used to determine overexpression (> or = 5% of nuclei labeled). Survival was analyzed using the Kaplan-Meier method, and statistical analysis was performed by using log rank testing and the Cox regression model. RESULTS: Median follow-up was 3.5 years. On univariate analysis of disease-specific mortality, significant prognostic factors were high grade (n = 42, 53%), positive microscopic margins (n = 36, 46%) or macroscopic margins (n = 15, 19%), and cyclin D1 overexpression (n = 37, 47%). On multivariate analysis, macroscopically positive margins (P = 0.02) and the combination of high grade and cyclin D1 overexpression (P = 0.04) both were associated independently with poor survival. CONCLUSION: High grade retroperitoneal sarcomas demonstrating cyclin D1 overexpression have had an extremely poor prognosis. Continued study of multiple biological markers, exemplified by cyclin D1, may aid characterization of tumor behavior and response to treatment in this diverse group of tumors.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/142807
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/1097-0142(20010115)91:2%3C428::AID-CNCR1018%3E3.0.CO;2-%23/full
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
Yonsei Authors
조남훈(Cho, Nam Hoon)
Export
RIS (EndNote)
XLS (Excel)
XML
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse