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급성백혈병환자에서 항암치료 후에 발생한 비중격천공을 동반한 외비함몰

Other Titles
 Saddle Nose & Septal Perforation Associated with Chemotherapy in Patients with Acute Leukemia 
 김현웅  ;  문형진  ;  양우익  ;  윤주헌 
 Korean Journal of Otolaryngology (대한이비인후과학회지), Vol.44(7) : 768-771, 2001 
Journal Title
 Korean Journal of Otolaryngology (대한이비인후과학회지) 
Issue Date
Saddle nose ; Septal perforation ; Chemotherapy ; Acute leukemia
To date, no cases of nasal septal perforation during or after chemotherapy in patients with acute leukemia have been reported. In this study, we report three acute leukemia patients that had septal perforation and saddle nose deformity after chemotherapy and the results of our attempts to determine the causes of this phenomenon. We investigated retrospectively the types of chemotherapeutic agents involved and the duration of chemotherapy until the development of the nasal septal perforation. In addition, we also studied whether there were any remaining malignant cells by biopsy from the septal perforation margin. We found that Ara-C was the only drug that was used in all 3 patients. Nasal septal perforation and saddle nose developed approximately 4∼7 weeks after the chemotherapy. A biopsy revealed inflammatory cells but no malignant cell infiltration. In cases of saddle nose associated with septal perforation after the chemotherapy for acute leukemia, one may consider the possibility of side effects of Ara-C. Furthermore, more active diagnosis and treatment are required when patients with acute leukemia complain of epistaxis or nasal obstruction during or after chemotherapy.
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1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Yoon, Joo Heon(윤주헌)
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