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Expression of Th2 Cytokines Decreases the Development of and Improves Behçet's Disease–Like Symptoms Induced by Herpes Simplex Virus in Mice

Authors
 Seonghyang Sohn  ;  Eun-So Lee  ;  Hyuk Jae Kwon  ;  Seung Ihm Lee  ;  Dongsik Bang  ;  Sungnack Lee 
Citation
 JOURNAL OF INFECTIOUS DISEASES, Vol.183(8) : 1180-1186, 2001 
Journal Title
 JOURNAL OF INFECTIOUS DISEASES 
ISSN
 0022-1899 
Issue Date
2001
MeSH
Animals ; Behcet Syndrome/pathology ; Behcet Syndrome/prevention & control* ; Behcet Syndrome/virology* ; Clodronic Acid/administration & dosage ; Clodronic Acid/pharmacology ; Disease Models, Animal ; Drug Carriers ; Herpes Simplex/complications ; Herpes Simplex/immunology* ; Herpes Simplex/pathology ; Herpesvirus 1, Human ; Humans ; Interleukin-4/biosynthesis* ; Liposomes ; Macrophages/immunology ; Macrophages/pathology ; Male ; Mice ; Mice, Inbred ICR ; Ovalbumin/immunology ; Spleen/immunology ; Th2 Cells/immunology*
Abstract
In the etiology of Behçet's disease (BD), viral infection has long been postulated as a contributing factor, and viral involvement has been demonstrated. However, viral infection alone is not sufficient to explain the pathogenesis of BD, and some evidence suggests that immunologic abnormalities are also important. To study the possible role of immune regulation in the development of BD-like symptoms induced by herpes simplex virus inoculation in ICR mice, macrophages were deleted by use of liposome-encapsulated clodronate (lip-Cl2MDP). Treatment with lip-Cl2MDP suppressed the development of BD-like symptoms, and this suppression was correlated with the induction of interleukin-4 expression in mouse spleens. When the Th2 adjuvant ovalbumin (OVA)–alum was injected into mice with BD-like symptoms, their cutaneous symptoms improved. Adoptive transfer with splenocytes from OVA-alum–injected mice also resulted in improvement. These findings suggest that up-regulated Th2 cytokine expression can attenuate the development of and improve some BD-like symptoms
Files in This Item:
T200102838.pdf Download
DOI
10.1086/319681
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Bang, Dong Sik(방동식)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/142708
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