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Differentiation of Neuroepithelial Progenitor Cells Implanted into Newborn Rat Brain Striatum

Authors
 Dong Soo Yeon ; Sung Choon Kwon ; Taick Sang Nam ; Jean Ju Lee ; Jung Sun Park 
Citation
 Korean Journal of Physiology & Pharmacology, Vol.5(1) : 9~17, 2001 
Journal Title
 Korean Journal of Physiology & Pharmacology 
ISSN
 1226-4512 
Issue Date
2001
Abstract
It has been demonstrated that multipotent neuronal progenitor cells can be isolated from the developing or adult CNS and proliferated in vitro in response to epidermal growth factor. The present study was undertaken to investigate the differentiation of neuronal progenitor cells after transplantation into the neonatal rat forebrain striatum. Primary cultured progenitor cells were labeled with 3,3'-dioctadecycloxacarbonyl- amine perchlorate (DiO). DiO labeled progenitor cells were implanted into neonatal rat striatum. Implanted DiO labeled progenitor cells were differentiated into astrocytes and GABAergic neurons. These results suggest that implanted progenitor cells can be differentiated into neurons in host forebrain striatum. In addition, our data show that DiO labeling is a useful technique for tracing implanted progenitor cells.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/142699
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Physiology
Yonsei Authors
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