Cited 11 times in
Effects of dextromethorphan on nocturnal behavior and brain c-Fos expression in adolescent rats
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김동구 | - |
dc.date.accessioned | 2016-02-19T11:13:58Z | - |
dc.date.available | 2016-02-19T11:13:58Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 0014-2999 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/142690 | - |
dc.description.abstract | Dextromethorphan, an antitussive widely available over-the-counter, is abused, mostly by teenagers at high doses. In our previous report, a high dose of dextromethorphan activated the midbrain dopamine neurons of adolescent rats. In the present study, we performed c-Fos immunohistochemistry in the dopaminergic terminal regions of adolescent rat brain after the intraperitoneal administration of dextromethorphan at different doses (0, 10, 20, and 40 mg/kg), and also examined the effects on nocturnal behavior. The results showed that dextromethorphan increased c-Fos expression dose dependently in the anterior cingulate cortex, caudate putamen, nucleus accumbens, and central amygdala. Significant ataxia occurred and both locomotor and rearing activity decreased immediately after the dextromethorphan injection. We conclude that the neurons in the reward pathway of the adolescent rat brain appear to be activated by a single injection of dextromethorphan, and that activation of this pathway by dextromethorphan may correlate with the behavioral effects and abuse potential of the drug. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 47~52 | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF PHARMACOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Behavior, Animal/drug effects | - |
dc.subject.MESH | Brain/drug effects* | - |
dc.subject.MESH | Brain/metabolism | - |
dc.subject.MESH | Dextromethorphan/pharmacology* | - |
dc.subject.MESH | Dose-Response Relationship, Drug | - |
dc.subject.MESH | Excitatory Amino Acid Antagonists/pharmacology* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | Locomotion/drug effects | - |
dc.subject.MESH | Proto-Oncogene Proteins c-fos/metabolism* | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Time Factors | - |
dc.title | Effects of dextromethorphan on nocturnal behavior and brain c-Fos expression in adolescent rats | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학) | - |
dc.contributor.googleauthor | Jeong Won Jahng | - |
dc.contributor.googleauthor | Tie Yuan Zhang | - |
dc.contributor.googleauthor | Seoul Lee | - |
dc.contributor.googleauthor | Dong Goo Kim | - |
dc.identifier.doi | 10.1016/S0014-2999(01)01409-1 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00396 | - |
dc.relation.journalcode | J00842 | - |
dc.identifier.eissn | 1879-0712 | - |
dc.identifier.pmid | 11716842 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0014299901014091 | - |
dc.subject.keyword | Dextromethorphan | - |
dc.subject.keyword | c-Fos | - |
dc.subject.keyword | Drug abuse | - |
dc.subject.keyword | Nocturnal behavior | - |
dc.subject.keyword | Reward pathway | - |
dc.contributor.alternativeName | Kim, Dong Goo | - |
dc.contributor.affiliatedAuthor | Kim, Dong Goo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 431 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 47 | - |
dc.citation.endPage | 52 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF PHARMACOLOGY, Vol.431(1) : 47-52, 2001 | - |
dc.identifier.rimsid | 29771 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.