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Differential antinociceptive effect of transcutaneous electrical stimulation on pain behavior sensitive or insensitive to phentolamine in neuropathic rats

Authors
 Taick Sang Nam  ;  Yoon Choi  ;  Dong Soo Yeon  ;  Joong Woo Leem  ;  Kwang Se Paik 
Citation
 NEUROSCIENCE LETTERS, Vol.301(1) : 17-20, 2001 
Journal Title
 NEUROSCIENCE LETTERS 
ISSN
 0304-3940 
Issue Date
2001
MeSH
Adrenergic alpha-Antagonists/pharmacology* ; Animals ; Cold Temperature ; Hindlimb/drug effects ; Hyperalgesia/therapy* ; Male ; Pain Measurement/drug effects* ; Pain Measurement/methods ; Peripheral Nervous System Diseases/therapy* ; Phentolamine/pharmacology* ; Rats ; Rats, Sprague-Dawley ; Spinal Nerves/injuries ; Touch ; Transcutaneous Electric Nerve Stimulation*
Keywords
Neuropathic pain ; Electrical stimulation ; Mechanical allodynia ; Cold hyperalgesia ; Naloxone ; Sympathetic dependency
Abstract
The effects of transcutaneous electrical stimulation and systemic injection of phentolamine, a non-specific alpha-adrenergic antagonist, on the behavioral signs of mechanical allodynia and cold hyperalgesia in rats with nerve injury were investigated. Mechanical allodynia and cold hyperalgesia were evaluated by measuring the paw withdrawal frequency (PWF) resulting from repetitive application of a von Frey hair and the paw lift duration (PLD) at a cold temperature, respectively. After a unilateral nerve injury, both PWF and PLD increased in the injured hind paw. Application of low-frequency, high-intensity transcutaneous electrical stimulation (LFHI-TES) to the injured hind paw depressed the injury-induced increased PWF, whereas it had no effect on the injury-induced increased PLD. Naloxone reversed the LFHI-TES produced depression of PWF. Intraperitoneal administration of phentolamine depressed the injury-induced increased PLD without affecting the injury-induced increased PWF. Our results suggest that LFHI-TES, which activates the endogenous opioid systems, produces an antinociceptive effect that appears to be related to whether or not the pain is mediated by sympathetic activity.
Full Text
http://www.sciencedirect.com/science/article/pii/S0304394001015877
DOI
10.1016/S0304-3940(01)01587-7
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Nam, Taick Sang(남택상)
Leem, Joong Woo(임중우) ORCID logo https://orcid.org/0000-0002-1605-2230
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/142688
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