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Characteristics of B cell mitogen isolated from Korean style fermentted soybean paste
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김주덕 | - |
dc.contributor.author | 이봉기 | - |
dc.date.accessioned | 2016-02-19T11:11:34Z | - |
dc.date.available | 2016-02-19T11:11:34Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 1017-7825 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/142603 | - |
dc.description.abstract | Korean-style fermented soybean paste (KFSP), Doenjang, is a traditional food that is consumed as a protein source in Korea. Recently, efforts to identify biolgocial response modifiers (BRMs) have been focused on food products. Accordingly, this study which isolated abiologically active substance form KFSP, named KFSP-BRM, ws defined to be aheat-stable carbohydrate with a molecular weight of 2,000 kDa. The biological activity of KFSP-BRM was not inactivated by treatment with an anti-LPS antibody. The oral as well as intraperitoneal treatment of mice with KFSP-BRM significantly enhanced the number of B cells expressing surface significantly enhanced the number of B cells expressing surface immunoglobulins (IgM and IgG). Subsequently, an increased level of immunoglobulins in the sera was also observed. In vitro. KFSP-BRM was found to upregulate the production of interleukin-1 (IL-1) and IL-6 by mactro phages and B cells but not the production of IL-2 by T cells. In conclusion, these data demonstrate the presence of a BRM in KFSP, which may provide an additional benefit to those consuming it is a food. KFSP-BRM is a novel B cellmitogen distinct from fresh soybean lectin or B cell mitogens, such as LPS and Streptococcus protein A. The major biological effects of KFSP-BRM would appear to be anincreased production of IL-1 and IL-6 by macrophages and B cells, thereby enhancing the function of mature B cells. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 143~152 | - |
dc.relation.isPartOf | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Characteristics of B cell mitogen isolated from Korean style fermentted soybean paste | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학) | - |
dc.contributor.googleauthor | Lee Bong Ki | - |
dc.contributor.googleauthor | Kwak Yi Sub | - |
dc.contributor.googleauthor | Jang Yun Soo | - |
dc.contributor.googleauthor | Kim Joo Deuk | - |
dc.contributor.googleauthor | Chung Kun Sub | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00932 | - |
dc.contributor.localId | A02806 | - |
dc.relation.journalcode | J01594 | - |
dc.identifier.eissn | 1738-8872 | - |
dc.subject.keyword | KFSP | - |
dc.subject.keyword | BRM | - |
dc.subject.keyword | B cells | - |
dc.subject.keyword | cytokine | - |
dc.subject.keyword | mitogen | - |
dc.subject.keyword | spleen index | - |
dc.subject.keyword | immunoglobulin | - |
dc.subject.keyword | LPS | - |
dc.contributor.alternativeName | Kim, Joo Deuk | - |
dc.contributor.alternativeName | Lee, Bong Ki | - |
dc.contributor.affiliatedAuthor | Kim, Joo Deuk | - |
dc.contributor.affiliatedAuthor | Lee, Bong Ki | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 11 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 143 | - |
dc.citation.endPage | 152 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, Vol.11(1) : 143-152, 2001 | - |
dc.identifier.rimsid | 31129 | - |
dc.type.rims | ART | - |
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