100 180

Cited 0 times in

Characteristics of B cell mitogen isolated from Korean style fermentted soybean paste

DC FieldValueLanguage
dc.contributor.author김주덕-
dc.contributor.author이봉기-
dc.date.accessioned2016-02-19T11:11:34Z-
dc.date.available2016-02-19T11:11:34Z-
dc.date.issued2001-
dc.identifier.issn1017-7825-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/142603-
dc.description.abstractKorean-style fermented soybean paste (KFSP), Doenjang, is a traditional food that is consumed as a protein source in Korea. Recently, efforts to identify biolgocial response modifiers (BRMs) have been focused on food products. Accordingly, this study which isolated abiologically active substance form KFSP, named KFSP-BRM, ws defined to be aheat-stable carbohydrate with a molecular weight of 2,000 kDa. The biological activity of KFSP-BRM was not inactivated by treatment with an anti-LPS antibody. The oral as well as intraperitoneal treatment of mice with KFSP-BRM significantly enhanced the number of B cells expressing surface significantly enhanced the number of B cells expressing surface immunoglobulins (IgM and IgG). Subsequently, an increased level of immunoglobulins in the sera was also observed. In vitro. KFSP-BRM was found to upregulate the production of interleukin-1 (IL-1) and IL-6 by mactro phages and B cells but not the production of IL-2 by T cells. In conclusion, these data demonstrate the presence of a BRM in KFSP, which may provide an additional benefit to those consuming it is a food. KFSP-BRM is a novel B cellmitogen distinct from fresh soybean lectin or B cell mitogens, such as LPS and Streptococcus protein A. The major biological effects of KFSP-BRM would appear to be anincreased production of IL-1 and IL-6 by macrophages and B cells, thereby enhancing the function of mature B cells.-
dc.description.statementOfResponsibilityopen-
dc.format.extent143~152-
dc.relation.isPartOfJOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleCharacteristics of B cell mitogen isolated from Korean style fermentted soybean paste-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Microbiology (미생물학)-
dc.contributor.googleauthorLee Bong Ki-
dc.contributor.googleauthorKwak Yi Sub-
dc.contributor.googleauthorJang Yun Soo-
dc.contributor.googleauthorKim Joo Deuk-
dc.contributor.googleauthorChung Kun Sub-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00932-
dc.contributor.localIdA02806-
dc.relation.journalcodeJ01594-
dc.identifier.eissn1738-8872-
dc.subject.keywordKFSP-
dc.subject.keywordBRM-
dc.subject.keywordB cells-
dc.subject.keywordcytokine-
dc.subject.keywordmitogen-
dc.subject.keywordspleen index-
dc.subject.keywordimmunoglobulin-
dc.subject.keywordLPS-
dc.contributor.alternativeNameKim, Joo Deuk-
dc.contributor.alternativeNameLee, Bong Ki-
dc.contributor.affiliatedAuthorKim, Joo Deuk-
dc.contributor.affiliatedAuthorLee, Bong Ki-
dc.rights.accessRightsfree-
dc.citation.volume11-
dc.citation.number1-
dc.citation.startPage143-
dc.citation.endPage152-
dc.identifier.bibliographicCitationJOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, Vol.11(1) : 143-152, 2001-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.