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Neural phenotype expression of cultured human cord blood cells in vitro

Authors
 Yoon Ha  ;  Joong Uhn Choi  ;  Do Heum Yoon  ;  Dong Soo Yeon  ;  Jean Ju Lee  ;  Hyun Ok Kim  ;  Yong Eun Cho 
Citation
 NEUROREPORT, Vol.12(16) : 3523-3527, 2001 
Journal Title
NEUROREPORT
ISSN
 0959-4965 
Issue Date
2001
MeSH
Cell Differentiation/physiology ; Cells, Cultured ; Fetal Blood/cytology ; Fetal Blood/metabolism* ; Humans ; Monocytes/cytology ; Monocytes/metabolism ; Neurons/cytology ; Neurons/metabolism* ; Phenotype ; Stem Cells/cytology ; Stem Cells/metabolism
Keywords
Cord blood cells ; GFAP (glial fibrillary acidic protein) ; MAP2 ; NeuN (neuronal nuclear antigen) ; Neural differentiation ; Neural stemcells ; Neurofilament
Abstract
Neural stem cells have been proposed as useful vectors for treating diseases in the CNS, but their utility is severely limited by lack of accessibility. Brain development is ongoing extensively in early postnatal life. However, it is unclear whether stem cells that differentiate into neurons exist in the blood during early postnatal life. We showed in this experiment that neural markers (NeuN, neurofilament, MAP2, GFAP) are expressed and long cytoplasmic processes are elaborated in the cultured human cord blood monocytes prepared from newborn umbilical blood. These results suggest that stem cells in human cord blood may be potential sources of neurons in early postnatal life. We suggest that the neonatal blood system functions as a circulating pool of different types of stem cell.
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00001756-200111160-00030&LSLINK=80&D=ovft
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyun Ok(김현옥) ORCID logo https://orcid.org/0000-0002-4964-1963
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/142574
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