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Neural phenotype expression of cultured human cord blood cells in vitro

Authors
 Yoon Ha  ;  Joong Uhn Choi  ;  Do Heum Yoon  ;  Dong Soo Yeon  ;  Jean Ju Lee  ;  Hyun Ok Kim  ;  Yong Eun Cho 
Citation
 Neuroreport, Vol.12(16) : 3523-3527, 2001 
Journal Title
 Neuroreport 
ISSN
 0959-4965 
Issue Date
2001
Abstract
Neural stem cells have been proposed as useful vectors for treating diseases in the CNS, but their utility is severely limited by lack of accessibility. Brain development is ongoing extensively in early postnatal life. However, it is unclear whether stem cells that differentiate into neurons exist in the blood during early postnatal life. We showed in this experiment that neural markers (NeuN, neurofilament, MAP2, GFAP) are expressed and long cytoplasmic processes are elaborated in the cultured human cord blood monocytes prepared from newborn umbilical blood. These results suggest that stem cells in human cord blood may be potential sources of neurons in early postnatal life. We suggest that the neonatal blood system functions as a circulating pool of different types of stem cell.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/142574
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실)
Yonsei Authors
김현옥(Kim, Hyun Ok)
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