Cited 28 times in
Multiple ligand interaction of α-synuclein produced various forms of protein aggregates in the presence of Aβ25-35, copper, and eosin
DC Field | Value | Language |
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dc.contributor.author | 김종선 | - |
dc.date.accessioned | 2016-02-19T11:10:27Z | - |
dc.date.available | 2016-02-19T11:10:27Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 0006-8993 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/142563 | - |
dc.description.abstract | Various protein aggregates of α-synuclein developed by way of the common protein self-oligomerization in the presence of Aβ25-35, copper, and eosin were examined. All the aggregates exhibited congo red birefringence although the actual amounts of the aggregates were varied as determined by thioflavin T binding fluorescence. When their morphologies were analyzed in relation to in vitro cytotoxicity, the smallest granular aggregates obtained with copper exhibited the highest cytotoxicity, while the fibrous structures by eosin did not affect the cell. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 93~98 | - |
dc.relation.isPartOf | BRAIN RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Amyloid beta-Peptides/metabolism* | - |
dc.subject.MESH | Cells, Cultured/drug effects | - |
dc.subject.MESH | Cells, Cultured/metabolism | - |
dc.subject.MESH | Copper/metabolism* | - |
dc.subject.MESH | Eosine Yellowish-(YS)/metabolism* | - |
dc.subject.MESH | Fluorescent Dyes/chemistry* | - |
dc.subject.MESH | Fluorescent Dyes/toxicity | - |
dc.subject.MESH | Ligands | - |
dc.subject.MESH | Microscopy, Electron | - |
dc.subject.MESH | Nerve Tissue Proteins/drug effects | - |
dc.subject.MESH | Nerve Tissue Proteins/metabolism* | - |
dc.subject.MESH | Nerve Tissue Proteins/ultrastructure | - |
dc.subject.MESH | Neurodegenerative Diseases/metabolism* | - |
dc.subject.MESH | Neurodegenerative Diseases/pathology | - |
dc.subject.MESH | Neurodegenerative Diseases/physiopathology | - |
dc.subject.MESH | Peptide Fragments/metabolism* | - |
dc.subject.MESH | Polymers/chemical synthesis | - |
dc.subject.MESH | Protein Structure, Tertiary/drug effects | - |
dc.subject.MESH | Protein Structure, Tertiary/physiology | - |
dc.subject.MESH | Synucleins | - |
dc.subject.MESH | Thiazoles/metabolism | - |
dc.subject.MESH | alpha-Synuclein | - |
dc.title | Multiple ligand interaction of α-synuclein produced various forms of protein aggregates in the presence of Aβ25-35, copper, and eosin | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학) | - |
dc.contributor.googleauthor | Young-Sik Kim | - |
dc.contributor.googleauthor | Daekyun Lee | - |
dc.contributor.googleauthor | Eun-Kyung Lee | - |
dc.contributor.googleauthor | Jee Young Sung | - |
dc.contributor.googleauthor | Kwang Chul Chung | - |
dc.contributor.googleauthor | Jongsun Kim | - |
dc.contributor.googleauthor | Seung R Paik | - |
dc.identifier.doi | 10.1016/S0006-8993(01)02575-6 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00921 | - |
dc.relation.journalcode | J00392 | - |
dc.identifier.eissn | 1872-6240 | - |
dc.identifier.pmid | 11457435 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0006899301025756 | - |
dc.subject.keyword | α-Synuclein | - |
dc.subject.keyword | Self-oligomerization | - |
dc.subject.keyword | Protein aggregation | - |
dc.subject.keyword | Cytotoxicity | - |
dc.subject.keyword | Parkinson’s disease | - |
dc.contributor.alternativeName | Kim, Jong Sun | - |
dc.contributor.affiliatedAuthor | Kim, Jong Sun | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 908 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 93 | - |
dc.citation.endPage | 98 | - |
dc.identifier.bibliographicCitation | BRAIN RESEARCH, Vol.908(1) : 93-98, 2001 | - |
dc.identifier.rimsid | 31094 | - |
dc.type.rims | ART | - |
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