67 86

Cited 0 times in

만성 특발성 두드러기 환자에서 high-affinity IgE 수용체에 대한 자가항체의 의의

Other Titles
 Autoantibody Against High Affinity IgE Receptor In Chronic Idiopathic Urticaria 
Authors
 이훈 ; 이승헌 ; 이광훈 ; 노재열 
Citation
 Korean Journal of Dermatology (대한피부과학회지), Vol.38(1) : 43~49, 2001 
Journal Title
 Korean Journal of Dermatology  (대한피부과학회지) 
ISSN
 0494-4739 
Issue Date
2001
Abstract
The pathogenesis of chronic idiopathic urticaria is not completely understood, but mast cell degranulation and histamine release are thought to be of central importance. It is now established that circulating autoantibodies against the high-affinity IgE receptor (Fc ε RI α ) can be found approximately one third of patients with chronic idiopathic urticaria. These autoantibodies can be detected by in vivo autologous serum skin test and by in vitro basophil and mast cell histamine release assays as functional tests, and also can be confirmed by in vitro enzyme-linked immunosorbent assay to Fc ε RI α and Western blot analysis. Our purpose was to determine the proportion of patients with positive autologous serum skin test and anti-Fc ε RI α antibody in chronic idiopathic urticaria and whether there are differences between patients with and those without autoantibodies in the clinical features. Results are as follows: 1. Positive result to autologous serum skin test was 58.5% in 41 patients of chronic idiopathic urticaria. There was no significant difference of clinical features and laboratory tests between patients with positive skin test and those with negative results. 2. By enzyme-linked immunosorbent assay, anti-Fc ε RI α antibody was detected in sera from 34% of patients with chronic idiopathic urticaria. 3. In sera from 33% of patients with positive skin test and 35% of those with negative result, we could demonstrate anti-Fc ε RI α antibody by enzyme-linked immunosorbent assay. 4. There was no differences of clinical features and laboratory tests between the patients with autoantibodies to Fc ε RI α and those without, except female predominance and longer urticaria history in those with autoantibodies. Our results demonstrated anti-Fc ε RI α antibody in the sera of chronic idiopathic urticaria patients, but there was no differences of clinical features and laboratory tests between the patients with autoantibodies to Fc ε RI α and those without. And we could not demonstrate the correlation between autologous serum skin test and the occurrence of anti-Fc ε RI α antibody.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/142538
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Dermatology
Yonsei Authors
사서에게 알리기
  feedback
Files in This Item:
T200102445.pdfDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse