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양의 태아를 이용한 횡격막탈장의 실험(제 1부)

Other Titles
 Experimental Congenital Diaphragmatic Hernia in a Fetal Lamb Model (I) 
 한석주  ;  한애리  ;  박용원  ;  신동환  ;  김봉경  ;  양인숙  ;  황의호 
 Journal of the Korean Surgical Society (대한외과학회지), Vol.61(3) : 229-236, 2001 
Journal Title
 Journal of the Korean Surgical Society  (대한외과학회지) 
Issue Date
Purpose The purpose of this study was to construct a fetal animal model of congenital diaphragmatic hernia in a lamb under domestic environments. Methods Left-sided diaphragmatic hernias were created in seven fetal lambs at about 85 days’ gestation (experimental group). Three other fetal lambs did not receive any surgical procedure and served as control group. Four of these lambs (3 in the experimental group and 1 in the control group) were delivered after a sufficient intrauterine period. The morphological changes of lung development were compared between the two groups. Results Creation of diaphragmatic hernia resulted in marked hypoplasia in fetal lung development. In this experiment, the maternal mortality was 33.3%, and the fetal mortality was 60% which are relatively high as compared with previous reports. Conclusion From this data, the authors concluded that experimental fetal diaphragmatic hernia can be established although the technique for the measurement of gestational age, anesthesia and postoperative care should be improved to overcome domestic inexperience in using the lamb as an experimental animal.
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
Yonsei Authors
박용원(Park, Yong Won) ; 한석주(Han, Seok Joo)
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