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Antimicrobial resistance surveillance of bacteria in 1999 in Korea with a special reference to resistance of enterococci to vancomycin and gram-negative bacilli to third generation cephalosporin, imipenem, and fluoroquinolone

Authors
 K. Lee  ;  H. S. Lee  ;  S. J. Jang  ;  A. J. Park  ;  M. H. Lee  ;  W. K. Song  ;  Y. Chong 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.16(3) : 262-270, 2001 
Journal Title
 JOURNAL OF KOREAN MEDICAL SCIENCE 
ISSN
 1011-8934 
Issue Date
2001
MeSH
Anti-Bacterial Agents/pharmacology* ; Anti-Infective Agents/pharmacology* ; Cephalosporins/pharmacology* ; Drug Resistance, Microbial ; Enterobacteriaceae/drug effects ; Enterococcus/drug effects* ; Fluoroquinolones ; Gram-Negative Bacteria/drug effects* ; Humans ; Imipenem/pharmacology* ; Korea ; Microbial Sensitivity Tests ; Pseudomonas aeruginosa/drug effects ; Vancomycin Resistance*
Keywords
Antimicrobial Drug Resistance in Korea ; Resistance Surveillance ; Vancomycin-Resistant Enterococci ; Imipenem-Resistant Pseudomonas
Abstract
The trend of antimicrobial resistance of bacteria isolated from patients in 30 Korean hospitals in 1999 was analyzed with a particular attention to cefotaxime- or fluoroquinolone-resistant gram-negative bacilli, imipenem-resistant Pseudomonas aeruginosa, and vancomycin-resistant enterococci. Adequacy of susceptibility testing, and any change in the frequencies of isolated species were also analyzed. The results showed that only 20% and 30% of hospitals tested the piperacillin-tazobactam and cefoxitin susceptibility of Enterobacteriaceae, respectively, only 24% of hospitals the piperacillin-tazobactam susceptibility of P. aeruginosa, and 17% of hospitals the fusidic acid susceptibility of staphylococci. Among the isolates 26.3% were glucose-nonfermenting gram-negative bacilli, and 34.7% of Enterococcus were Enterococcus faecium. Slight decline of cefotaxime-resistance rate to 20% was noted in Klebsiella pneumoniae, while fluoroquinolone-resistance rate was 68% in Acinetobacter baumannii. The ceftazidime- and imipenem-resistance rates were 17% and 18%, respectively in P. aeruginosa. The vancomycin-resistance rate of E. faecium rose significantly to 15.1%, but the rates varied significantly depending on hospitals suggesting presence of different degree of selective pressure or nosocomial spread. In conclusion, the prevalence of imipenem-resistant P. aeruginosa and the increase of vancomycin-resistant E. faecium were the particularly worrisome phenomena observed in this study.
Files in This Item:
T200102346.pdf Download
DOI
10.3346/jkms.2001.16.3.262
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/142489
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