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Vascular Endothelial Growth Factor (VEGF)-C Differentially Affects Tumor Vascular Function and Leukocyte Recruitment: Role of VEGF-Receptor 2 and Host VEGF-A 1
DC Field | Value | Language |
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dc.contributor.author | 윤채옥 | - |
dc.date.accessioned | 2016-02-19T11:08:00Z | - |
dc.date.available | 2016-02-19T11:08:00Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 0008-5472 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/142470 | - |
dc.description.abstract | Unlike vascular endothelial growth factor (VEGF)-A, the effect of VEGF-C on tumor angiogenesis, vascular permeability, and leukocyte recruitment is not known. To this end, we quantified in vivo growth and vascular function in tumors derived from two VEGF-C-overexpressing (VC+) and mock-transfected cell lines (T241 fibrosarcoma and VEGF-A−/− embryonic stem cells) grown in murine dorsal skinfold chambers. VC+ tumors grew more rapidly than mock-transfected tumors and exhibited parallel increases in tumor angiogenesis. Furthermore, VEGF-C overexpression elevated vascular permeability in T241 tumors, but not in VEGF-A−/− tumors. Surprisingly, unlike VEGF-A, VEGF-C did not increase leukocyte rolling or adhesion in tumor vessels. Administration of VEGF receptor (VEGFR)-2 neutralizing antibody DC101 reduced vascular density and permeability of both VC+ and mock-transduced T241 tumors. These data suggest that VEGFR-2 signaling is critical for tumor angiogenesis and vascular permeability and that VEGFR-3 signaling does not compensate for VEGFR-2 blockade. An alternate VEGFR, VEGFR-1 or neuropilin-1, may modulate adhesion of leukocytes to tumor vessels. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 2404~2408 | - |
dc.relation.isPartOf | CANCER RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Capillary Permeability/physiology | - |
dc.subject.MESH | Cell Communication/physiology | - |
dc.subject.MESH | Cell Division/physiology | - |
dc.subject.MESH | Endothelial Growth Factors/biosynthesis | - |
dc.subject.MESH | Endothelial Growth Factors/genetics | - |
dc.subject.MESH | Endothelial Growth Factors/physiology* | - |
dc.subject.MESH | Endothelium, Vascular/pathology | - |
dc.subject.MESH | Leukocytes/pathology* | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, SCID | - |
dc.subject.MESH | Neoplasms, Experimental/blood supply* | - |
dc.subject.MESH | Neoplasms, Experimental/metabolism | - |
dc.subject.MESH | Neoplasms, Experimental/pathology | - |
dc.subject.MESH | Neovascularization, Pathologic/genetics | - |
dc.subject.MESH | Neovascularization, Pathologic/metabolism | - |
dc.subject.MESH | Neovascularization, Pathologic/physiopathology* | - |
dc.subject.MESH | RNA/biosynthesis | - |
dc.subject.MESH | RNA/genetics | - |
dc.subject.MESH | Receptor Protein-Tyrosine Kinases/antagonists & inhibitors | - |
dc.subject.MESH | Receptor Protein-Tyrosine Kinases/physiology* | - |
dc.subject.MESH | Receptors, Growth Factor/antagonists & inhibitors | - |
dc.subject.MESH | Receptors, Growth Factor/physiology* | - |
dc.subject.MESH | Receptors, Vascular Endothelial Growth Factor | - |
dc.subject.MESH | Vascular Endothelial Growth Factor A | - |
dc.subject.MESH | Vascular Endothelial Growth Factor C | - |
dc.title | Vascular Endothelial Growth Factor (VEGF)-C Differentially Affects Tumor Vascular Function and Leukocyte Recruitment: Role of VEGF-Receptor 2 and Host VEGF-A 1 | - |
dc.type | Article | - |
dc.contributor.college | Researcher Institutes (부설 연구소) | - |
dc.contributor.department | Institute for Cancer Research (암연구소) | - |
dc.contributor.googleauthor | Ananth Kadambi | - |
dc.contributor.googleauthor | Carla Mouta Carreira | - |
dc.contributor.googleauthor | Chae-ok Yun | - |
dc.contributor.googleauthor | Timothy P. Padera | - |
dc.contributor.googleauthor | Dennis E. J. G. J. Dolmans | - |
dc.contributor.googleauthor | Peter Carmeliet | - |
dc.contributor.googleauthor | Dai Fukumura | - |
dc.contributor.googleauthor | Rakesh K. Jain | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02614 | - |
dc.relation.journalcode | J00452 | - |
dc.identifier.eissn | 1538-7445 | - |
dc.identifier.pmid | 11289105 | - |
dc.contributor.alternativeName | Yun, Chae Ok | - |
dc.contributor.affiliatedAuthor | Yun, Chae Ok | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 61 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 2404 | - |
dc.citation.endPage | 2408 | - |
dc.identifier.bibliographicCitation | CANCER RESEARCH, Vol.61(6) : 2404-2408, 2001 | - |
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