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Patterns of wave break during ventricular fibrillation in isolated swine right ventricle

Authors
 Moon-Hyoung Lee  ;  Zhilin Qu  ;  Gregory A. Fishbein  ;  Scott T. Lamp  ;  Eugene H. Chang  ;  Toshihiko Ohara  ;  Olga Voroshilovsky  ;  Jong R. Kil  ;  Ali R. Hamzei  ;  Nina C. Wang  ;  Shien-Fong Lin  ;  James N. Weiss  ;  Alan Garfinkel  ;  Hrayr S. Karagueuzian  ;  Peng-Sheng Chen 
Citation
 AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Vol.281(1) : 253-265, 2001 
Journal Title
 AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 
ISSN
 0363-6135 
Issue Date
2001
MeSH
Action Potentials ; Animals ; Computer Simulation ; Imaging, Three-Dimensional ; In Vitro Techniques ; Models, Cardiovascular ; Optics and Photonics ; Reaction Time ; Signal Processing, Computer-Assisted ; Swine ; Ventricular Fibrillation/physiopathology* ; Ventricular Function, Right*
Abstract
Several different patterns of wave break have been described by mapping of the tissue surface during fibrillation. However, it is not clear whether these surface patterns are caused by multiple distinct mechanisms or by a single mechanism. To determine the mechanism by which wave breaks are generated during ventricular fibrillation, we conducted optical mapping studies and single cell transmembrane potential recording in six isolated swine right ventricles (RV). Among 763 episodes of wave break (0.75 times · s−1 · cm−2), optical maps showed three patterns: 80% due to a wave front encountering the refractory wave back of another wave, 11.5% due to wave fronts passing perpendicular to each other, and 8.5% due to a new (target) wave arising just beyond the refractory tail of a previous wave. Computer simulations of scroll waves in three-dimensional tissue showed that these surface patterns could be attributed to two fundamental mechanisms: head-tail interactions and filament break. We conclude that during sustained ventricular fibrillation in swine RV, surface patterns of wave break are produced by two fundamental mechanisms: head-tail interaction between waves and filament break.
Files in This Item:
T200102280.pdf Download
DOI
10.1152/ajpheart.2001.281.1.H253
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Moon-Hyoung(이문형) ORCID logo https://orcid.org/0000-0002-7268-0741
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/142464
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