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Granzyme B and TIA-1 Expression in Chronic and Acute on Chronic Renal Allograft Rejection

 Soon Won Hong  ;  Hyeon Joo Jeong  ;  Soon Il Kim  ;  Jang Il Moon  ;  Yu Seun Kim  ;  Kiil Park 
 Yonsei Medical Journal, Vol.42(3) : 285-290, 2001 
Journal Title
 Yonsei Medical Journal 
Issue Date
Although active inflammation may be deleterious and indicate immunologic activation in chronically rejected grafts, the underlying mechanism of tissue destruction has been little studied. Twenty-four cases of chronic rejection (CR) with or without acute rejection (AR) were stained with antibodies against CD3, CD8, CD68, granzyme B and TIA-1, and the number of positive cells were counted. Eleven cases of AR served as controls. The number of CD3 and CD8 positive cells increased in the acute on CR group compared to the CR group. About a half of CD3 positive T cells were CD8 positive in both groups, however, the proportion of TIA-1 or granzyme B positive cells was higher in the acute on CR group. The numbers of CD3, CD68, granzyme B and TIA-1 positive cells were higher in the AR group than the acute on CR group, however, no significant difference was found between the two groups. Serum creatinine level and proteinuria at the time of biopsy and the percentages of late onset AR and graft failure rate were higher in the acute on CR group than the CR group. Summarizing, these results suggest that infiltration of activated T cells containing cytotoxic granules plays a role in graft destruction in acute on CR.
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
Yonsei Authors
김유선(Kim, Yu Seun) ; 정현주(Jeong, Hyeon Joo) ; 홍순원(Hong, Soon Won)
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