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Combined chemotherapy and radiation versus radiation alone in the management of localized angiocentric lymphoma of the head and neck

Authors
 Gwi Eon Kim  ;  Sang-wook Lee  ;  Sei Kyung Chang  ;  Hee Chul Park  ;  Hong Ryull Pyo  ;  Joo Hang Kim  ;  Sun Rock Moon  ;  Hyeong Sik Lee  ;  Eun Chang Choi  ;  Kwang Moon Kim 
Citation
 Radiotherapy and Oncology, Vol.61(3) : 261-269, 2001 
Journal Title
 Radiotherapy and Oncology 
ISSN
 0167-8140 
Issue Date
2001
Abstract
BACKGROUND AND PURPOSE: To clarify the clinical benefit derived from the combined modality therapy (CMT) comprised of chemotherapy and involved-field radiotherapy (XRT) for stage I and II angiocentric lymphomas of the head and neck. MATERIAL AND METHODS: Of 143 patients with angiocentric lymphoma of the head and neck treated at the Yonsei Cancer Center between 1976 and 1995, 104 patients (XRT group) received involved-field XRT alone with a median dose of 50.4 Gy (range: 20-70 Gy), while 39 patients (CMT group) received a median three cycles (range: 1-6 cycles) of chemotherapy before starting involved-field XRT. The response rate, patterns of failure, complications, and survival data of the XRT group were compared with those of the CMT group. RESULTS: Despite a higher response rate, local failure was the most common pattern of failure in patients of the both groups. The patterns of failure, including the systemic relapse rate were not influenced by the addition of combination chemotherapy. Although both modalities were well tolerated by the majority of patients, aberrant immunologic disorders or medical illnesses, such as a hemophagocytic syndrome, sepsis, intractable hemorrhage, or the evolution of second primary malignancies were more frequently observed in patients of the CMT group. The prognosis of patients in the XRT group was relatively poor, with a 5-year overall actuarial survival rate of 38% and disease-free survival rate of 32%, respectively. However, their clinical outcome was not altered by the addition of systemic chemotherapy. Achieving complete remission was the most important prognostic factor on univariate and multivariate analyses, but treatment modality was not found to be a prognostic variable influencing survival. CONCLUSIONS: Involved-field XRT alone for angiocentric lymphoma of the head and neck was insufficient to achieve an improved survival rate, but the combination of chemotherapy and involved-field XRT failed to demonstrate any therapeutic advantage over involved-field XRT alone.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/142413
DOI
10.1016/S0167-8140(01)00428-5
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실)
Yonsei Authors
김귀언(Kim, Gwi Eon) ; 김주항(Kim, Joo Hang)
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Full Text
http://www.sciencedirect.com/science/article/pii/S0167814001004285
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