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모야모야병에서 염기성 섬모 세포 성장 인자의 역할

Other Titles
 The role of basic fibroblast growth factor in moyamoya disease 
 김동석  ;  최중언  ;  김세혁  ;  양국희  ;  김현숙 
 Journal of Korean Neurosurgical Society (대한신경외과학회지), Vol.30(1) : 5-11, 2001 
Journal Title
 Journal of Korean Neurosurgical Society (대한신경외과학회지) 
Issue Date
Angiogenesis ; Basic fibroblast growth factor ; Encephalo-duro-arterio-synangiosis ; Moyamoya disease
Objectives and Importance:The present study investigated the levels of basic fibroblast growth factor(bFGF) in the CSF of patients with moyamoya disease and its clinical significance. Methods:The levels of bFGF in CSF, taken from 26 hemispheres of 14 moyamoya patients and 20 patients without vascular anomaly(control group), were measured by an enzyme-linked immunosorbent assay. We analyzed the correlation between the level of bFGF and the clinical factors such as age, onset pattern, development of neovascularization, and cerebral circulation. Results:The CSF of moyamoya patients contained a high concentration of bFGF to a significant extent. The bFGF level was apparently elevated in the patients in whom neovascularization from indirect revascularization, such as modified encephalo-duro-arterio-synangiosis(EDAS) was well developed. A linear correlation between the values of bFGF and clinical progression was noted. Conclusions:The elevation of bFGF in moyamoya disease seems to be specific. Clinically, the bFGF level may be considered a useful indicator to predict the efficacy of indirect revascularization.
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1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Seok(김동석)
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