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정신분열병 환자의 사건관련전위와 신경심리검사 수행간의 상관 연구

Other Titles
 The Correlational Study of Event - Related Potential ( ERP ) and the Performance of Neuropsychological Tests in Schizophrenic Patients 
 김명선  ;  조상수  ;  박수진  ;  김용식  ;  김재진  ;  권준수 
 Korean Journal of Clinical Psychology (한국심리학회지: 임상), Vol.20(2) : 359-373, 2001 
Journal Title
 Korean Journal of Clinical Psychology (한국심리학회지: 임상) 
Issue Date
schizophrenia ; event-related potential ; neuropsychological test ; N200 ; P300
This study investigated the cognitive impairment and neurophysiological mechanism of schizophrenia by event-related potential(ERP) and neuropsychological tests. The patient group showed significantly reduced P300 amplitude and prolonged P200, N200, P300 latency than control group. In terms of neuropsychological tests, schizophrenic patients showed impaired performance on tests evaluating problem-solving, verbal learning and verbal memory. The amplitude and latency of P200 and N200 were correlated with performance of Trail-Making Test(B) and Object Alternation Test(OAT), while the late cognitive peak, P300, was correlated with performance of Verbal learning Test(LNVLT) and Wisconsin Card Sorting Test(WCST). These results indicate that the schizophrenic patient has impairment of information-processing, and this impairment begins to emerge from the early stages of information-processing such as encoding, identification and classification of stimulus. P200 and N200 seem to be affected by subject`s attention or mental flexibility, while P300 is associated with higher cognitive functions such as problem-solving, verbal learning and verbal memory. These results also indicate that schizophrenia is related to the structural or functional abnormalities of various cortical areas including frontal and temporal lobe rather than a circumscribed cortical area.
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1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
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