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Acute Eosinophilic Pneumonia Associated with Amitriptyline in a Hemodialysis Patient

Authors
 Hyunjin Noh  ;  Young Kyu Lee  ;  Shin Wook Kang  ;  Kyu Hun Choi  ;  Dae Suk Han  ;  Ho Yung Lee 
Citation
 YONSEI MEDICAL JOURNAL, Vol.42(3) : 357-359, 2001 
Journal Title
 YONSEI MEDICAL JOURNAL 
ISSN
 0513-5796 
Issue Date
2001
MeSH
Acute Disease ; Adult ; Amitriptyline/adverse effects* ; Antidepressive Agents, Tricyclic/adverse effects* ; Female ; Humans ; Pulmonary Eosinophilia/etiology* ; Renal Dialysis*
Keywords
amitriptyline ; eosinophilic pnemonia ; hemodialysis
Abstract
Drugs are well known causes of eosinophilic lung disease. In many patients, drug-induced eosinophilic lung disease presents with transient eosinophilic infiltrates that disappear after discontinuation of the drug. Some patients, however, experience a fulminant, acute eosinophilia-like disease. Recently, we experienced a case of amitriptyline-associated acute eosinophilic pneumonia with respiratory failure in a diabetic hemodialysis patient. Eight days after treatment with amitriptyline, sudden fever, chill, dry cough and dyspnea developed. Subsequently, multiple patch consolidations appeared on the chest radiographs. Bronchoalveolar lavage (BAL), established a diagnosis of acute eosinophilic pneumonia. After immediate discontinuation of amitriptyline, a rapid clinical and radiological improvement was observed. The present case indicates that the possibility of acute eosinophilic pneumonia should be fully considered in dialysis patients developing unexplained respiratory symptoms while on amitriptyline therapy.
Files in This Item:
T200102093.pdf Download
DOI
10.3349/ymj.2001.42.3.357
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Choi, Kyu Hun(최규헌) ORCID logo https://orcid.org/0000-0003-0095-9011
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/142367
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