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우울장애 환자에서 Nefazodone의 항우울효과, 항불안효과 및 수면·성기능·삶의 질 등에 미치는 영향에 관한 다기관 연구

Other Titles
 A Multicenter Study on Effects of Nefazodone on Depression, Anxiety, Sleep, Sexual Fuctions, and Quality of Life in Patients with Depression 
 민성길  ;  강병조  ;  정인과  ;  조맹제  ;  윤진상  ;  김동기  ;  강민희  ;  김도관  ;  김명정  ;  김석현  ;  김용구  ;  김정기  ;  박민철  ;  방계원  ;  손봉기  ;  신지용 
 Korean Journal of Psychopharmacology (대한정신약물학회지), Vol.12(3) : 211-221, 2001 
Journal Title
 Korean Journal of Psychopharmacology (대한정신약물학회지) 
Issue Date
Nefazodone ; Antidepressant effect ; Anxiety ; Sleep disturbance ; Sexual dysfunction.
OBJECTIVE: The aim of this study is to determine effects of nefazodone on depression, anxiety, sleep and sexual function in depressive patients. SUBJECTS AND METHODS: This is an open, non-comparative, multi-center study. Antidepressant and other clinical effects of nefazodone were evaluated in 230 patients of 26 centers, aged 14 years or more, who met DSM-IV criteria to major depressive disorder or dysthymic disorder and didn't have other psychiatric disorders and were physically healthy. The clinical efficacy was assessed at week 1, 2, 4 and 8 using Clinical Global Improvement (CGI), Hamilton Depression Scale (HAM-D), Beck Depression Inventory (BDI), State and Trait Anxiety Inventory-State Anxiety (STAI-SA). Other clinical effects were assessed with Weekly Sleep Questionnaire, Sexual Functioning Questionnaire and GHQ-QOL-12, a scale for quality of life. Adverse drug reactions were checked with a questionnaire. Post-treatment effects of drug were compared with pre-treatment baseline condition. RESULTS: The response rates by Clincal Grobal Improvement and HAM-D after 8 weeks treatment were 62.4% and 75.2% respectively. Comparing to baseline, nefazodone was proved to have significantly higher antidepressant and antianxiety effects in depressive patients and it improved also sleep, sexual functions and quality of life. Both patients and physicians satisfied with the effects of drug. Adverse drug reactions were a few and not serious, and most of them disappeared as treatment continued. CONCLUSION: These results suggest that not only nefazodone has antidepressant effects and antianxiety effects, but also it improves sleep disturbance, sexual dysfunction and the quality of life in depressive patients. Adverse drug reactions were a few and not serious.
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1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Min, Sung Kil(민성길)
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