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고온 열처리한 돼지 해면골의 화학, 구조적 평가와 골형성능에 대한 연구

Other Titles
 Chemical, Structural & Osteoconductive Properties of Mineralized Porcine Cancellous Bone 
 김수향  ;  박문수  ;  김은정  ;  신정욱  ;  양우익  ;  김성재  ;  이진우 
 Journal of Korean Orthopaedic Research Society (대한정형외과연구학회지), Vol.4(2) : 89-95, 2001 
Journal Title
 Journal of Korean Orthopaedic Research Society (대한정형외과연구학회지) 
Issue Date
Porcine cancellous bone ; Mineralization ; Chemical ; Structural ; Osteoconductivity
Purpose: The purpose of this study is to determine the efficacy of bioactive hydroxyapatite obtained from the porcine cancellous bone for the treatment of bone defect and nonunion. Materials and Methods: Porcine cancellous bones were heat-treated at 1300℃ for 2 hours. The chemical compositions, calcium to phosphate ratio and microstructures of mineralized porcine bone were examined. For in vivo implantation, bone defects were made on the anteromedial aspects of proximal tibia in 7 beagle dogs and theses artificial bones were inserted. Plain X-ray was taken at every 2 weeks interval for radiologic evaluation. At 12 weeks, specimens were evaluated histologyically with hematoxylin and eosin stain. Results: The composition and morphology of mineralized porcine cancellous bone were similar to those of heat-treated human cancellous bone. Radiographs showed union at the host bone-bone block interfaces. At 12 weeks, all uniform and substantial new bone formation were observed. Conclusion: This mineralization technique has several advantages such as no disease transmission, no immune reaction, excellent biocompatibility, and cost-effectiveness. Consequently, mineralized porcine cancellous bone showed an effective osteoconductivity.
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1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Jin Woo(이진우) ORCID logo https://orcid.org/0000-0002-0293-9017
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