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개에서 심폐회로시 심박출량의 변화 및 혈관수축·이완제가 중심-말초동맥압 및 혈류량에 미치는 영향

Other Titles
 Is Central to Peripheral Arterial Pressure Gradient Influenced by Cardiac Output and Vasoactive Drugs in Canines Undergoing Cardiopulmonary Bypass? 
 곽영란  ;  박영환  ;  심연희  ;  강상화  ;  오영준  ;  이용경  ;  홍용우 
 Journal of Korean Society of Anesthesiologist (대한마취과학회지), Vol.40(1) : 67-73, 2001 
Journal Title
 Journal of Korean Society of Anesthesiologist (대한마취과학회지) 
Issue Date
heart ; cardiopulmonary bypass ; monitoring ; blood flow ; blood pressure
Background: It has been known that radial arterial pressure sometimes underestimates central pressure after cardiopulmonary bypass (CPB) and status of circulatory volume, vascular tone, hemodilution or rewarming were explained as the major causes of this phenomenon. We evaluated the effects of these variables on blood pressure and flow in radial and femoral arteries in dogs undergoing CPB. Methods: Both radial and femoral arteries were cannulated for pressure monitoring and the opposite side arteries were exposed for the measurement of blood flow in 9 dogs. Radial arterial pressure (RBP), femoral arterial pressure (FBP), aortic pressure (ABP), radial blood flow (RBF), and femoral blood flow (FBF) were measured before and just after the initiation of CPB. All values were also recorded when pump flow or ABP were changed during hypothermic CPB and after rewarming. Results: Unlike patients with cardiac disease, RBP, FBP and ABP were almost the same and changes in pump flow and vasoactive drugs didn't make any clinically significant pressure difference between RBP and ABP during hypothermic CPB or after rewarming in the normal condition of dogs. RBF was constantly maintained when the ABP increased with phenylephrine or decreased with sodium nitroprusside (SNP). However, FBF markedly increased during SNP infusion. Conclusions: Cardiac output, vasoactive drugs and even CPB didn't exert any effect on RBP and FBP in dogs with a normal cardiovascular system. Cardiovascular abnormalities and vascular change or hemodynamic instability itself may induce a large discrepancy between RBP and ABP in cardiac patients undergoing CPB.
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1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Kwak, Young Lan(곽영란) ORCID logo https://orcid.org/0000-0002-2984-9927
Shim, Yon Hee(심연희) ORCID logo https://orcid.org/0000-0003-1921-3391
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