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Transplantation of peripheral blood stem cells mobilized by intensified consolidation and granulocyte colony-stimulating factor in acute leukemia

 Yoo Hong Min  ;  Seung Tae Lee  ;  Jin Seok Kim  ;  Joon Ho Jang  ;  Hyung Chan Suh  ;  Hyun Ok Kim  ;  Jae Sook Hahn  ;  Yun Woong Ko 
 YONSEI MEDICAL JOURNAL, Vol.42(1) : 65-73, 2001 
Journal Title
Issue Date
Adult ; Female ; Hematopoiesis ; Hematopoietic Stem Cell Mobilization* ; Hematopoietic Stem Cell Transplantation*/adverse effects ; Humans ; Leukemia, Myeloid, Acute/mortality ; Leukemia, Myeloid, Acute/therapy* ; Male ; Middle Aged ; Transplantation, Autologous
peripheral blood stem cell ; transplantation ; acute leukemia
The purpose of this study was to evaluate the feasibility and efficacy of autologous transplantation of peripheral blood stem cells (PBSC) mobilized with high-dose consolidation chemotherapy and granulocyte colony-stimulating factor in patients with acute myelogenous leukemia (AML). Twenty patients received myeloablative chemotherapy or chemo-radiotherapy including total body irradiation followed by the infusion of PBSC. PBSC were collected by large-volume leukaphereses. The mean number of mononuclear cells and CD34-positive cells infused were 7.2 × 108/kg (range, 2.2-16.6), and 6.6 × 106/kg (range, 2.1-27.7), respectively. Engraftment failure was not seen in the enrolled patients. The median time to neutrophil (≥ 500/µL) and platelet recovery (≥ 50,000/µL) from the transplant was 12 days (range, 8-20) and 28 days (range, 10-600), respectively. The 2-year probability of disease-free survival (DFS) and relapse were 43% and 57% for patients with AML transplanted in first complete remission (CR1). The outcome of the patients transplanted in the advanced status was significantly worse than the patients transplanted in CR1 (P=0.04). Most relapses occurred within 1 year after transplantation. Fatal hepatic veno-occlusive disease was observed in one case. Other transplantation-related toxicities were mild. Our results demonstrated that autologous transplantation of high-dose consolidation chemotherapy-mobilized peripheral blood progenitor cells is feasible in the patients with AML in CR1. To further reduce the risk of leukemia relapse, much effort should be contributed to the field of ex vivo purging and post-transplant immunotherapy.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyun Ok(김현옥) ORCID logo https://orcid.org/0000-0002-4964-1963
Min, Yoo Hong(민유홍) ORCID logo https://orcid.org/0000-0001-8542-9583
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