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아토피피부염 환자에서 집먼지진드기에 대한 탈감작 요법의 치료효과

Other Titles
 Effect of Hyposensitization to Dermatophagoides farinae in Patients with Atopic Dermatitis 
 최유진  ;  최현주  ;  조흔정  ;  김수민  ;  박중원  ;  홍천수  ;  이광훈 
 Korean Journal of InvestigativeDermatology (대한피부연구학회지), Vol.8(2) : 123-128, 2001 
Journal Title
Korean Journal of InvestigativeDermatology(대한피부연구학회지)
Issue Date
Atopic dermatitis ; hyposensitization
BACKGROUND : Exposure to airborne allergens exacerbates symptoms of atopic dermatitis in sensitive patients and immunotherapy specific for an allergen can reduce the allergen-specific immune response.

OBJECTIVES : We attempted to evaluate the therapeutic effect of hyposensitization therapy using Dermatophagoides farinae, the most abundant and important inhalant allergen in Korea, in patients with atopic dermatitis.

METHODS : Twenty-five patients with atopic dermatitis who had severe dermatitis, positive to the skin test and had specific antibodies to D. farinae were treated with hyposensitization therapy using D. farinae for 1 year. The therapeutic effect was evaluated by clinical severity (erythema, excoriation, scale, pruritus, lichenification), D. farinae specific IgE, IgG, IgG4, skin test to D. farinae, total IgE, eosinophil count and
soluble VCAM-1.

RESULTS : There was slight improvement in clinical severity and decrease in eosinophil count and D. farinae specific IgE, but no significant difference in skin test to D. farinae, total IgE, D. farinae specific IgG, IgG4 and soluble VCAM-1 after hyposensitization therapy with D. farinae.

CONCLUSION : The efficacy of hyposensitization therapy may be useful in some of patients with atopic dermatitis. Further new effective immunotherapeutic approaches to atopic dermatitis and searching for laboratory markers of predicting disease severity will be needed.
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1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Kwang Hoon(이광훈)
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