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삼출성 중이염에서 삼출액의 점도에 따른 조성의 차이

Other Titles
 Compositional Difference of Middle Ear Effusion according to Viscosity of the Effusion 
 최재영  ;  윤주헌  ;  이원상  ;  정명현 
 Korean Journal of Otolaryngology (대한이비인후과학회지), Vol.44(2) : 124-128, 2001 
Journal Title
Korean Journal of Otolaryngology(대한이비인후과학회지)
Issue Date
Otitis media with effusion (OME) ; Mucin ; Lysozyme ; Interleukin-8 ; MUC5AC
Background and Objectives : Serous otitis media (SOM) is usually responsive to medical treatment, whereas mucoid otitis media (MOM) is not This study was undertaken to elucidate the compositional difference between serous and mucoid effusion, and to investigate whether MUC5AC acts as a major mucin in the middle ear mucosa with MOM. Materials and Methods : Middle ear effusion (MEE) samples were collected from 29 patients with MOM and 20 patients with SOM. The level of mucin, lysozyme, secretory IgA and interleukin-8 were measured by dot blotting or enzyme-linked immunosorbent assay. Periodic acid-Schiff and immunohistochemical staining with monoclonal anti-MUC5AC antibody were performed on the serial sections of middle ear mucosa with MOM.
Results : Mucoid effusions contained higher levels of mucin, lysozyme, secretory IgA and interleukin-8 than serous effusion. Immunohistological study revealed that MUC5AC mucin was expressed in only a small portion of the goblet cells of middle ear mucosa with MOM. Conclusion : Our study suggests that both serous secretions and mucin might make the middle ear effusion more viscous, and that mucins other than MUC5AC might have a major role in the viscosity of MEE. Further study is necessary to identify the major mucins in the MEE of otitis media with effusion.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Yoon, Joo Heon(윤주헌)
Chung, Myung Hyun(정명현)
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