Dry Skin, termed xerosis by dermatologists, refers to a common skin type that is generally drier and less oily. Flaky, itchy skin is often observed on the face, arms or legs. Certain disease states, such as diabetes, liver and kidney abnormalities, and other internal problems can also result in dry skin. As we age, our skin becomes increasingly drier. This is due in part to a decrease in the production of sebum and natural moisturizing factors. More recently, new research has indicated that the skin barrier fuction plays significant role as well. As the best way to improve the skin barrier function, supplying ceramide of pseudo-ceramide externally, natural moisturizing factors and sebum should be considered and the adjustable vehicles to maintain skin barrier function and skin homeostasis.