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Teratoid Hepatoblastoma: Multidirectional Differentiation of Stem Cell of the Liver

Authors
 Lucia Kim  ;  Young Nyun Park  ;  Sung Eun Kim  ;  Tae Woong Noh  ;  Chanil Park 
Citation
 YONSEI MEDICAL JOURNAL, Vol.42(4) : 431-435, 2001 
Journal Title
 YONSEI MEDICAL JOURNAL 
ISSN
 0513-5796 
Issue Date
2001
MeSH
Cell Differentiation ; Female ; Hepatoblastoma/pathology* ; Humans ; Infant ; Liver/pathology* ; Liver Neoplasms/pathology* ; Stem Cells/pathology*
Keywords
Hepatoblastoma ; teratoid ; multidirectional differ-entiation ; stem cell ; liver ; chemotherapy
Abstract
Hepatoblastoma is the most common malignant hepatic neoplasm of childhood, showing a wide spectrum of epithelial and mesenchymal components. Teratoid hepatoblastoma, which reveals multiple lines of tissue differentiation such as mucinous epithelium, melanin pigment, endocrine differentiation, glial and mesenchymal components, has rarely been observed. We report a case of teratoid hepatoblastoma in a 22-month-old girl. She had been diagnosed with hepatoblastoma through percutaneous needle biopsy of the liver and treated with 10 chemotherapy cycles of epirubicin, VP-16 and cisplatin and with hepatic artery embolization. After 10 months, an extended left lobectomy was performed. Grossly, a multinodular, partly well-demarcated, solid mass (7 × 5 cm) with dense fibrosis and focal cystic change occupied almost the entire specimen. There was extensive necrosis due to preoperative treatment. Microscopically, the tumor showed multiple lines of differentiation, which was composed of embryonal, fetal hepatocytes and mesenchymal elements with numerous foci of osteoid. There were also other components showing endodermal, neural, melanocytic and endocrine differentiation. These teratoid components were considered relatively resistant to preoperative chemotherapy, in contrast to extensive necrosis of both embryonal and fetal hepatocytes. These teratoid features of hepatoblastoma are considered to be a multidirectional differentiation of the small epithelial cells or stem cells of the tumor.
Files in This Item:
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DOI
10.3349/ymj.2001.42.4.431
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Park, Young Nyun(박영년) ORCID logo https://orcid.org/0000-0003-0357-7967
Park, Chan Il(박찬일)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/142109
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