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Modulation of QT Interval by Cardiac Sympathetic Nerve Sprouting and the Mechanisms of Ventricular Arrhythmia in a Canine Model of Sudden Cardiac Death

Authors
 SHENGMEI ZHOU  ;  JI-MIN CAO  ;  ZACH D. TEBB  ;  TOSHIHIKO OHARA  ;  HSUN-LUN A. HUANG  ;  CHIKAYA OMICHI  ;  MOON-HYOUNG LEE  ;  BRUCE H. KENKNIGHT  ;  LAN S. CHEN  ;  MICHAEL C. FISHBEIN  ;  HRAYR S. KARAGUEUZIAN  ;  PENG-SHENG CHEN 
Citation
 JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, Vol.12(9) : 1068-1073, 2001 
Journal Title
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
ISSN
 1045-3873 
Issue Date
2001
MeSH
Animals ; Death, Sudden, Cardiac/etiology* ; Disease Models, Animal ; Dogs ; Electrocardiography/drug effects ; Heart Block/etiology ; Heart Block/physiopathology ; Heart Rate/drug effects ; Myocardial Infarction/complications ; Myocardial Infarction/physiopathology ; Nerve Growth Factor/pharmacology* ; Nerve Regeneration ; Stellate Ganglion/drug effects* ; Stellate Ganglion/physiology ; Tachycardia, Ventricular/etiology* ; Ventricular Fibrillation/etiology*
Keywords
arrhythmia ; myocardial infarction ; heart block ; sudden death ; sympathetic nerve
Abstract
Introduction: We previously reported that there is a high incidence of sudden cardiac death (SCD) in dogs with myocardial infarction (MI), complete AV block (CAVB), and nerve growth factor (NGF) infusion to the left stellate ganglion (LSG). Whether or not QT interval prolongation underlines the mechanism of SCD was unclear.

Methods and Results: We analyzed QT intervals in three groups of dogs. All dogs had CAVB and MI. The LSG group (n = 9) and right stellate ganglion (RSG) group (n = 6) received NGF infusion via the osmotic pumps over a 5-week period to LSG and RSG, respectively. The control group (n = 6) received no NGF. The dogs either died suddenly or were sacrificed within 2 to 3 months after MI. Heart rhythm and QT and RR intervals were monitored using implantable cardioverter defibrillator ECG recordings. There was a time-dependent increase of QTc intervals in the LSG group and a time-dependent decrease of QTc intervals in the RSG group. At the end of NGF infusion, QTc intervals in the LSG group (408 ± 41 msec) were significantly longer than those in the control (350 ± 41 msec; P < 0.05) and RSG groups (294 ± 23 msec; P < 0.01). In the LSG group, 4 of 9 dogs died of SCD. There was no SCD in either the RSG or control group. Immunocytochemical staining showed NGF infusion to LSG and RSG resulted in left and right ventricular sympathetic nerve sprouting and hyperinnervation, respectively.

Conclusion: NGF infusion to the LSG in dogs with MI and CAVB resulted in increased QT interval and incidence of ventricular tachycardia, ventricular fibrillation, and SCD, whereas NGF infusion to the RSG shortened QT interval and reduced the incidence of ventricular tachycardia. These findings indicate that QT interval prolongation is causally related to the occurrence of ventricular arrhythmia in dogs with nerve sprouting, MI, and CAVB.
Full Text
http://onlinelibrary.wiley.com/doi/10.1046/j.1540-8167.2001.01068.x/abstract
DOI
10.1046/j.1540-8167.2001.01068.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Moon-Hyoung(이문형) ORCID logo https://orcid.org/0000-0002-7268-0741
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/142100
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