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식품을 통한 유기인계농약류의 동시노출위해성평가

Other Titles
 Cumulative Risk Assessment of Organophosphorus Pesticides in the Diet 
 이효민  ;  한지연  ;  윤은경  ;  김효미  ;  황인균  ;  최동미  ;  이강봉  ;  원경풍  ;  송인상 
 Korean Journal of Social and Personality Psychology (한국식품위생안전성학회지), Vol.16(1) : 21-26, 2001 
Journal Title
Korean Journal of Social and Personality Psychology(한국식품위생안전성학회지)
Issue Date
cumulative risk assessment ; AChE inhibition ; organophosphorus pesticide ; hazard index
Risk assessment traditionally are conducted on individual chemicals; however, humans are exposed to multiple chemicals in daily life. The organophosphorus (OP) pesticides are considered in a single risk assessment because they act by a common mechanism of toxicity, and there is likely to be expose to multiple OP pesticides simultaneously or sequentially. The OP pesticides act by inhibiting the enzyme acetylcholinesterasc (AChE) and have available extensive database. AChE is widely distributed throughout the body, most importantly in the nervous system. Inhibition of AChE results in accumulation of acetylcholine in the nervous system that results in clinical signs of cholinergic toxicity, including increased salivation and lacrimation, nausea and vomiting, muscle fasciculation, lethargy and fatigue, among others. To conduct an exposure assessment for pesticides in the diet, we need to know the food consumption patterns of the populations, and the pesticide residue levels in the foods that are consumed. This study was conducted to identify cumulative dietary risk due to multiple OP pesticides that can be exposed through various foods. Total 22 food samples including cereals, vegetables and fruits were collected randomly two times from food markets in several sites (4 cities). The subjected foods were selected by regarding of highly consumed foods to general Korean people. The 12 OP pesticides including Acephate, Azinphos-methyl, Chlorpyrifos, and Diazinon were monitored. For the exposure assessment, general adult group of 60 kg body weight was regarded as target population and food consumption data suggested by Lee et al. (2000) were used as consumed value of individual food. Analyses of samples for OP pesticides have been carried out according to the multiclass multiresidue analysis method and acephate and methamidophos analysis method of Korea Food Code. In general the levels of OP pesticides found in the food samples were very low or not detected.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
Yonsei Authors
Shin, Dong Chun(신동천) ORCID logo https://orcid.org/0000-0003-4252-2280
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