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연령별 전립선특이항원의 정상 참고치 : 경상남도 남해군 지역 역학적 조사

Other Titles
 Age-Specific Reference Ranges for Serum Prostate-Specific Antigen: Community-based Survey in Namhae Region 
Authors
 최영득  ;  홍성준  ;  나군호  ;  차경빈  ;  마상열  ;  이무상  ;  송재석  ;  최종락  ;  김현숙  ;  김봉환 
Citation
 KOREAN JOURNAL OF UROLOGY, Vol.42(8) : 834-839, 2001 
Journal Title
 KOREAN JOURNAL OF UROLOGY 
ISSN
 0494-4747 
Issue Date
2001
Keywords
Prostate specific antigen ; Prostate ; Age-specific reference range
Abstract
Purpose: To establish the relationship between serum prostate specific antigen (PSA) concentration and age in a community-based population without clinically evident prostate cancer, a population based screening study was performed in a rural area in Southern Korea.Materials and Methods: From January 1999 to December 1999, 1,278 volunteer men aged from 40 to 89 years in Namhae, Korea participated in a clinical examination that included a serum PSA determination (TANDEM-R assay), digital rectal examination and transrectal ultrasonography. The subjects who had clinical evidence of prostate cancer and high PSA concentration (>10ng/ml) were excluded. The PSA levels were compared with age using Pearson correlation and linear regression analysis.Results: The serum PSA concentration correlated with patient age (r=0.129, p=0.001). The observed 95th percentile increased from 1.37ng/ml for subjects in the 40`s to 6.18ng/ml for subjects in the 80'2. The reference range for serum PSA (95 percentile) for men in the 40’s was 0.24 to 1.37ng/ml; for 50 to 59 years, 0.27 to 2.68ng/ml; for 60 to 69 years, 0.25 to 4.00ng/ml; for 70 to 79 years, 0.29 to 4.55ng/ml; and for 80 to 89 years, 0.31 to 6.18ng/ml.Conclusions: Our data showed that the serum PSA concentration directly correlated with patient age (Pearson correlation coefficient=0.129, P=0.001). Thus, rather than relying on a single reference range regardless of different age groups, it may be more appropriate to have age-specific reference ranges. Our data were lower than that of the Western data, and could provide an adjunctive information in interpreting PSA data in Korean men, especially in the elderly population.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Rha, Koon Ho(나군호) ORCID logo https://orcid.org/0000-0001-8588-7584
Choi, Young Deuk(최영득) ORCID logo https://orcid.org/0000-0002-8545-5797
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/142079
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