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Coffee Consumption and Serum Lipids: A Meta-Analysis of Randomized Controlled Clinical Trials

 Sun Ha Jee  ;  Jiang He  ;  Lawrence J. Appel  ;  Paul K. Whelton  ;  II Suh  ;  Michael J. Klag 
 American Journal of Epidemiology, Vol.153(4) : 353-362, 2001 
Journal Title
 American Journal of Epidemiology 
Issue Date
Adult ; Cholesterol/blood* ; Cholesterol, LDL/blood* ; Cholesterol, LDL/drug effects ; Coffee/adverse effects* ; Female ; Food Handling/methods ; Humans ; Male ; Middle Aged ; Randomized Controlled Trials as Topic
clinical trials ; coffee ; lipids ; meta-analysis
Coffee drinking has been associated with increased serum cholesterol levels in some, but not all, studies. A Medline search of the English-language literature published prior to December 1998, a bibliography review, and consultations with experts were performed to identify 14 published trials of coffee consumption. Information was abstracted independently by two reviewers using a standardized protocol. With a random-effects model, treatment effects were estimated by pooling results from individual trials after weighting the results by the inverse of total variance. A dose-response relation between coffee consumption and both total cholesterol and LDL cholesterol was identified (p < 0.01). Increases in serum lipids were greater in studies of patients with hyperlipidemia and in trials of caffeinated or boiled coffee. Trials using filtered coffee demonstrated very little increase in serum cholesterol. Consumption of unfiltered, but not filtered, coffee increases serum levels of total and LDL cholesterol.
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1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Suh, Il(서일) ORCID logo https://orcid.org/0000-0002-9689-7849
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
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