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평균 적혈구 혈색소 농도를 이용한 유전성구상적혈구증과 혈관내 용혈의 감별 진단. 

Other Titles
 Mean Corpuscular Hemoglobin Concentration as a Discriminating Tool between Hereditary Spherocytosis and Intravascular Hemolysis 
Authors
 박혜영  ;  김황민  ;  이경아  ;  원동일  ;  박세명  ;  박석원  ;  이백근  ;  김길영 
Citation
 Journal of the Korean Pediatric Association (소아과), Vol.44(6) : 664-668, 2001 
Journal Title
Journal of the Korean Pediatric Association(소아과)
ISSN
 1738-1061 
Issue Date
2001
Keywords
Mean coupscular hemoglobin concentration ; Hereditary spherocytosis
Abstract
Purpose : The purposes of this study were to elucidate the diagnostic significance of mean corpuscular hemoglobin concentration(MCHC) for various kinds of hemolytic anemia, the mechanism of elevated MCHC in hereditary spherocytosis(HS). Methods : The subjects consisted of 39 cases of HS(group 1), 31 cases of intravascular hemolysis (IH) such as DIC, snake bite or hemolytic uremic syndrome(group 3), and sex and age matched controls(group 2, 4) for group 1, 3, respectively. The pre- and postoperative MCHC values were compared in 32 splenectomised HS patients. The age of subjects ranged from 1 to 18 years old. MCHC values were obtained with a H2 Technicon automated counter. Results : The MCHC was 34.5¡¾2.3 g/dL, 33.0¡¾1.1 g/dL, 32.4¡¾2.0 g/dL and 32.7¡¾1.0 g/dL in group 1, 2, 3, and 4, respectively. The MCHC of group 1 was significantly higher than those of group 2, 3 and 4(P<0.05). ROC curve showed that HS could be discriminated from IH or a normal control when MCHC was above 35 g/dL with a sensitivity of 0.51 and a specificity of 0.96. There was a significant difference between pre- and postoperative MCHC values(34.1¡¾2.2 g/dL, 32.6¡¾2.7 g/dL, respectively) in splenectomised HS patients(P<0.05). Conclusion : The MCHC obtained with laser scattering cytometry was elevated in cases of HS, and was a good diagnostic tool for discriminating HS from either IH or a normal control in children. The mechanism of elevated MCHC in HS seems to be the result of splenic processing.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Kyung A(이경아) ORCID logo https://orcid.org/0000-0001-5320-6705
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141985
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